Apolipoprotein E is a Concentration-dependent Pulmonary Danger Signal that Activates the NLRP3 Inflammasome and IL-1β Secretion by Asthmatic Macrophages

Apolipoprotein E is a Concentration-dependent Pulmonary Danger Signal that Activates the NLRP3 Inflammasome and IL-1β Secretion by Asthmatic Macrophages

Apolipoprotein E is a concentration-dependent danger signal in the lung that can prime and activate the NLRP3 inflammasome in asthmatic macrophages to secrete IL-1β. This may promote and amplify inflammation when pulmonary APOE concentrations are increased above normal levels.

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Veröffentlicht in:Journal of allergy and clinical immunology 2019-03, Vol.144 (2), p.426-441.e3
Hauptverfasser: Gordon, Elizabeth M., Yao, Xianglan, Xu, Haitao, Karkowsky, William, Kaler, Maryann, Kalchiem-Dekel, Or, Barochia, Amisha V., Gao, Meixia, Keeran, Karen J., Jeffries, Kenneth R., Levine, Stewart J.
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Sprache:eng
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Zusammenfassung:Apolipoprotein E is a concentration-dependent danger signal in the lung that can prime and activate the NLRP3 inflammasome in asthmatic macrophages to secrete IL-1β. This may promote and amplify inflammation when pulmonary APOE concentrations are increased above normal levels.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2019.02.027