Insulin resistance persists despite a metabolically healthy obesity phenotype
Objective Metabolically healthy obesity (MHO) is often defined as the absence of metabolic syndrome in the presence of obesity. However, phenotypic features of MHO are unclear. Insulin sensitivity in MHO was cross‐sectionally compared with metabolically unhealthy obesity (MUO) and a reference group...
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| Veröffentlicht in: | Obesity (Silver Spring, Md.) Md.), 2022-01, Vol.30 (1), p.39-44 |
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| container_title | Obesity (Silver Spring, Md.) |
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| creator | Hoddy, Kristin K. Axelrod, Christopher L. Mey, Jacob T. Hari, Adithya Beyl, Robbie A. Blair, Jourdan B. Dantas, Wagner S. Kirwan, John P. |
| description | Objective
Metabolically healthy obesity (MHO) is often defined as the absence of metabolic syndrome in the presence of obesity. However, phenotypic features of MHO are unclear. Insulin sensitivity in MHO was cross‐sectionally compared with metabolically unhealthy obesity (MUO) and a reference group of young healthy participants without obesity.
Methods
Sedentary adults (n = 96) undergoing anthropometric, blood chemistries, maximal aerobic capacity, and euglycemic‐hyperinsulinemic clamp measurements were classified by BMI ( |
| doi_str_mv | 10.1002/oby.23312 |
| format | Article |
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Metabolically healthy obesity (MHO) is often defined as the absence of metabolic syndrome in the presence of obesity. However, phenotypic features of MHO are unclear. Insulin sensitivity in MHO was cross‐sectionally compared with metabolically unhealthy obesity (MUO) and a reference group of young healthy participants without obesity.
Methods
Sedentary adults (n = 96) undergoing anthropometric, blood chemistries, maximal aerobic capacity, and euglycemic‐hyperinsulinemic clamp measurements were classified by BMI (<25 and ≥30 kg/m2). MUO was defined as having obesity with metabolic syndrome (≥2 additional risk factors). Data were analyzed using a linear mixed models approach.
Results
Body weight was similar between MHO and MUO. Body fat (percentage) and high‐density lipoprotein cholesterol were higher (p < 0.001), and systolic blood pressure, triglycerides, glucose, and insulin were lower in MHO versus MUO (p < 0.03, all). The MHO group also had lower high‐density lipoprotein cholesterol and higher low‐density lipoprotein cholesterol, diastolic blood pressure, and insulin compared with the reference. Both the MHO and MUO groups displayed impaired insulin sensitivity compared with the reference control (p < 0.001).
Conclusions
Participants with MHO had distinct clinical measures related to hypertension, lipid metabolism, and glycemic control compared with a healthy reference group. Peripheral insulin resistance in obesity independent of metabolic status portends increased risk for type 2 diabetes in the MHO patient population.</description><identifier>ISSN: 1930-7381</identifier><identifier>EISSN: 1930-739X</identifier><identifier>DOI: 10.1002/oby.23312</identifier><identifier>PMID: 34816598</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Blood pressure ; Body fat ; Body Mass Index ; Cardiac stress tests ; Cholesterol ; Diabetes ; Diabetes Mellitus, Type 2 ; Exercise ; Genotype & phenotype ; Glucose ; High density lipoprotein ; Humans ; Insulin Resistance ; Lipoproteins ; Metabolic Syndrome ; Obesity ; Obesity, Metabolically Benign - epidemiology ; Phenotype ; Physical fitness ; Risk Factors</subject><ispartof>Obesity (Silver Spring, Md.), 2022-01, Vol.30 (1), p.39-44</ispartof><rights>2021 The Obesity Society</rights><rights>2021 The Obesity Society.</rights><rights>Copyright Blackwell Publishing Ltd. Jan 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4432-54015dd5a28a111d382df6e4effcf26b294f4fa5bcc91239af7204a0efb1e4363</citedby><cites>FETCH-LOGICAL-c4432-54015dd5a28a111d382df6e4effcf26b294f4fa5bcc91239af7204a0efb1e4363</cites><orcidid>0000-0002-5168-1155 ; 0000-0002-1444-8557</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Foby.23312$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Foby.23312$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,1427,27903,27904,45553,45554,46388,46812</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34816598$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hoddy, Kristin K.</creatorcontrib><creatorcontrib>Axelrod, Christopher L.</creatorcontrib><creatorcontrib>Mey, Jacob T.</creatorcontrib><creatorcontrib>Hari, Adithya</creatorcontrib><creatorcontrib>Beyl, Robbie A.</creatorcontrib><creatorcontrib>Blair, Jourdan B.</creatorcontrib><creatorcontrib>Dantas, Wagner S.</creatorcontrib><creatorcontrib>Kirwan, John P.</creatorcontrib><title>Insulin resistance persists despite a metabolically healthy obesity phenotype</title><title>Obesity (Silver Spring, Md.)</title><addtitle>Obesity (Silver Spring)</addtitle><description>Objective
Metabolically healthy obesity (MHO) is often defined as the absence of metabolic syndrome in the presence of obesity. However, phenotypic features of MHO are unclear. Insulin sensitivity in MHO was cross‐sectionally compared with metabolically unhealthy obesity (MUO) and a reference group of young healthy participants without obesity.
Methods
Sedentary adults (n = 96) undergoing anthropometric, blood chemistries, maximal aerobic capacity, and euglycemic‐hyperinsulinemic clamp measurements were classified by BMI (<25 and ≥30 kg/m2). MUO was defined as having obesity with metabolic syndrome (≥2 additional risk factors). Data were analyzed using a linear mixed models approach.
Results
Body weight was similar between MHO and MUO. Body fat (percentage) and high‐density lipoprotein cholesterol were higher (p < 0.001), and systolic blood pressure, triglycerides, glucose, and insulin were lower in MHO versus MUO (p < 0.03, all). The MHO group also had lower high‐density lipoprotein cholesterol and higher low‐density lipoprotein cholesterol, diastolic blood pressure, and insulin compared with the reference. Both the MHO and MUO groups displayed impaired insulin sensitivity compared with the reference control (p < 0.001).
Conclusions
Participants with MHO had distinct clinical measures related to hypertension, lipid metabolism, and glycemic control compared with a healthy reference group. Peripheral insulin resistance in obesity independent of metabolic status portends increased risk for type 2 diabetes in the MHO patient population.</description><subject>Blood pressure</subject><subject>Body fat</subject><subject>Body Mass Index</subject><subject>Cardiac stress tests</subject><subject>Cholesterol</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2</subject><subject>Exercise</subject><subject>Genotype & phenotype</subject><subject>Glucose</subject><subject>High density lipoprotein</subject><subject>Humans</subject><subject>Insulin Resistance</subject><subject>Lipoproteins</subject><subject>Metabolic Syndrome</subject><subject>Obesity</subject><subject>Obesity, Metabolically Benign - epidemiology</subject><subject>Phenotype</subject><subject>Physical fitness</subject><subject>Risk Factors</subject><issn>1930-7381</issn><issn>1930-739X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1P3DAQhq0KVJaPQ_9AFYkLPSzrsZ3gXCrBqhQkKi4gwclynHHXyBundgLKv2-2oSuK1NOMNM88mtFLyCegp0ApW4RqOGWcA_tAZlByOj_j5cPOtpewR_ZTeqJUFDSHj2SPCwlFXsoZ-XHdpN67JouYXOp0YzBrMW76lNWYWtdhprM1droK3hnt_ZCtUPtuNWShGpe6IWtX2IRuaPGQ7FrtEx691gNyf_ntbnk1v7n9fr08v5kbITib54JCXte5ZlIDQM0lq22BAq01lhUVK4UVVueVMSUwXmp7xqjQFG0FKHjBD8jXydv21Rprg00XtVdtdGsdBxW0U_9OGrdSP8OzKoEXUuaj4ORVEMOvHlOn1i4Z9F43GPqkWEGhlMAoHdHjd-hT6GMzvjdSjIuCSdgIv0yUiSGliHZ7DFC1CUmNIak_IY3s57fXb8m_qYzAYgJenMfh_yZ1e_E4KX8D2x-dpA</recordid><startdate>202201</startdate><enddate>202201</enddate><creator>Hoddy, Kristin K.</creator><creator>Axelrod, Christopher L.</creator><creator>Mey, Jacob T.</creator><creator>Hari, Adithya</creator><creator>Beyl, Robbie A.</creator><creator>Blair, Jourdan B.</creator><creator>Dantas, Wagner S.</creator><creator>Kirwan, John P.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5168-1155</orcidid><orcidid>https://orcid.org/0000-0002-1444-8557</orcidid></search><sort><creationdate>202201</creationdate><title>Insulin resistance persists despite a metabolically healthy obesity phenotype</title><author>Hoddy, Kristin K. ; Axelrod, Christopher L. ; Mey, Jacob T. ; Hari, Adithya ; Beyl, Robbie A. ; Blair, Jourdan B. ; Dantas, Wagner S. ; Kirwan, John P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4432-54015dd5a28a111d382df6e4effcf26b294f4fa5bcc91239af7204a0efb1e4363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Blood pressure</topic><topic>Body fat</topic><topic>Body Mass Index</topic><topic>Cardiac stress tests</topic><topic>Cholesterol</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2</topic><topic>Exercise</topic><topic>Genotype & phenotype</topic><topic>Glucose</topic><topic>High density lipoprotein</topic><topic>Humans</topic><topic>Insulin Resistance</topic><topic>Lipoproteins</topic><topic>Metabolic Syndrome</topic><topic>Obesity</topic><topic>Obesity, Metabolically Benign - epidemiology</topic><topic>Phenotype</topic><topic>Physical fitness</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hoddy, Kristin K.</creatorcontrib><creatorcontrib>Axelrod, Christopher L.</creatorcontrib><creatorcontrib>Mey, Jacob T.</creatorcontrib><creatorcontrib>Hari, Adithya</creatorcontrib><creatorcontrib>Beyl, Robbie A.</creatorcontrib><creatorcontrib>Blair, Jourdan B.</creatorcontrib><creatorcontrib>Dantas, Wagner S.</creatorcontrib><creatorcontrib>Kirwan, John P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Obesity (Silver Spring, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hoddy, Kristin K.</au><au>Axelrod, Christopher L.</au><au>Mey, Jacob T.</au><au>Hari, Adithya</au><au>Beyl, Robbie A.</au><au>Blair, Jourdan B.</au><au>Dantas, Wagner S.</au><au>Kirwan, John P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insulin resistance persists despite a metabolically healthy obesity phenotype</atitle><jtitle>Obesity (Silver Spring, Md.)</jtitle><addtitle>Obesity (Silver Spring)</addtitle><date>2022-01</date><risdate>2022</risdate><volume>30</volume><issue>1</issue><spage>39</spage><epage>44</epage><pages>39-44</pages><issn>1930-7381</issn><eissn>1930-739X</eissn><abstract>Objective
Metabolically healthy obesity (MHO) is often defined as the absence of metabolic syndrome in the presence of obesity. However, phenotypic features of MHO are unclear. Insulin sensitivity in MHO was cross‐sectionally compared with metabolically unhealthy obesity (MUO) and a reference group of young healthy participants without obesity.
Methods
Sedentary adults (n = 96) undergoing anthropometric, blood chemistries, maximal aerobic capacity, and euglycemic‐hyperinsulinemic clamp measurements were classified by BMI (<25 and ≥30 kg/m2). MUO was defined as having obesity with metabolic syndrome (≥2 additional risk factors). Data were analyzed using a linear mixed models approach.
Results
Body weight was similar between MHO and MUO. Body fat (percentage) and high‐density lipoprotein cholesterol were higher (p < 0.001), and systolic blood pressure, triglycerides, glucose, and insulin were lower in MHO versus MUO (p < 0.03, all). The MHO group also had lower high‐density lipoprotein cholesterol and higher low‐density lipoprotein cholesterol, diastolic blood pressure, and insulin compared with the reference. Both the MHO and MUO groups displayed impaired insulin sensitivity compared with the reference control (p < 0.001).
Conclusions
Participants with MHO had distinct clinical measures related to hypertension, lipid metabolism, and glycemic control compared with a healthy reference group. Peripheral insulin resistance in obesity independent of metabolic status portends increased risk for type 2 diabetes in the MHO patient population.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>34816598</pmid><doi>10.1002/oby.23312</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-5168-1155</orcidid><orcidid>https://orcid.org/0000-0002-1444-8557</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Obesity (Silver Spring, Md.), 2022-01, Vol.30 (1), p.39-44 |
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| source | Wiley-Blackwell Journals; MEDLINE; Wiley Free Archive |
| subjects | Blood pressure Body fat Body Mass Index Cardiac stress tests Cholesterol Diabetes Diabetes Mellitus, Type 2 Exercise Genotype & phenotype Glucose High density lipoprotein Humans Insulin Resistance Lipoproteins Metabolic Syndrome Obesity Obesity, Metabolically Benign - epidemiology Phenotype Physical fitness Risk Factors |
| title | Insulin resistance persists despite a metabolically healthy obesity phenotype |
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