Insulin resistance persists despite a metabolically healthy obesity phenotype

Insulin resistance persists despite a metabolically healthy obesity phenotype

Objective Metabolically healthy obesity (MHO) is often defined as the absence of metabolic syndrome in the presence of obesity. However, phenotypic features of MHO are unclear. Insulin sensitivity in MHO was cross‐sectionally compared with metabolically unhealthy obesity (MUO) and a reference group...

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Veröffentlicht in:Obesity (Silver Spring, Md.) Md.), 2022-01, Vol.30 (1), p.39-44
Hauptverfasser: Hoddy, Kristin K., Axelrod, Christopher L., Mey, Jacob T., Hari, Adithya, Beyl, Robbie A., Blair, Jourdan B., Dantas, Wagner S., Kirwan, John P.
Format: Artikel
Sprache:eng
Schlagworte:
Blood pressure
Body fat
Body Mass Index
Cardiac stress tests
Cholesterol
Diabetes
Diabetes Mellitus, Type 2
Exercise
Genotype & phenotype
Glucose
High density lipoprotein
Humans
Insulin Resistance
Lipoproteins
Metabolic Syndrome
Obesity
Obesity, Metabolically Benign - epidemiology
Phenotype
Physical fitness
Risk Factors
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Zusammenfassung:Objective Metabolically healthy obesity (MHO) is often defined as the absence of metabolic syndrome in the presence of obesity. However, phenotypic features of MHO are unclear. Insulin sensitivity in MHO was cross‐sectionally compared with metabolically unhealthy obesity (MUO) and a reference group of young healthy participants without obesity. Methods Sedentary adults (n = 96) undergoing anthropometric, blood chemistries, maximal aerobic capacity, and euglycemic‐hyperinsulinemic clamp measurements were classified by BMI (
ISSN:1930-7381
1930-739X
DOI:10.1002/oby.23312