Antiplatelet Activity of Riamilovir under Conditions of Lipopolysaccharide Intoxication

We studied the effect of antiviral agent riamilovir on ADP-induced platelet aggregation in the absence and presence of LPS. Unlike acetylsalicylic acid (reference drug), riamilovir did not exhibit antiplatelet effect in vitro . However, it markedly suppressed platelet reactivity in LPS-treated blood...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2022-05, Vol.173 (1), p.41-45
Hauptverfasser:	Spasov, A. A., Kucheryavenko, A. F., Sirotenko, V. S., Gaidukova, K. A., Uskov, G. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylsalicylic acid Acids Animals Antiviral agents Antiviral Agents - pharmacology Aspirin Aspirin - pharmacology Biomedical and Life Sciences Biomedicine Blood Blood Platelets Cell Biology Coronaviruses COVID-19 Cytokine storm Drug dosages Experiments Health aspects Influenza Internal Medicine Intoxication Laboratory Medicine Lipopolysaccharides Lipopolysaccharides - pharmacology Neutrophils Pathology Pharmacology Platelet Aggregation Platelet Aggregation Inhibitors - pharmacology Rats Salicylates Severe acute respiratory syndrome coronavirus 2 Thrombosis Toxicology Triazines Triazoles
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Zusammenfassung:	We studied the effect of antiviral agent riamilovir on ADP-induced platelet aggregation in the absence and presence of LPS. Unlike acetylsalicylic acid (reference drug), riamilovir did not exhibit antiplatelet effect in vitro . However, it markedly suppressed platelet reactivity in LPS-treated blood samples and was 2.2-fold superior to acetylsalicylic acid in terms of IC 50 value. In in vivo experiments, riamilovir under conditions of hypercytokinemia blocked platelet aggregation in rats by 64%.
ISSN:	0007-4888 1573-8221 1573-8221
DOI:	10.1007/s10517-022-05489-0