A genome-wide search for determinants of survival in 1926 patients with advanced colorectal cancer with follow-up in over 22,000 patients

While genome-wide association studies (GWAS) have identified germline variants influencing the risk of developing colorectal cancer (CRC), there has been limited examination of the possible role of inherited variation as a determinant of patient outcome. We performed a GWAS for overall survival (OS)...

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Veröffentlicht in:	European journal of cancer (1990) 2021-12, Vol.159, p.247-258
Hauptverfasser:	Wills, Christopher, He, Yazhou, Summers, Matthew G., Lin, Yi, Phipps, Amanda I., Watts, Katie, Law, Philip J., Al-Tassan, Nada A., Maughan, Timothy S., Kaplan, Richard, Houlston, Richard S., Peters, Ulrike, Newcomb, Polly A., Chan, Andrew T., Buchanan, Daniel D., Gallinger, Steve, Marchand, Loic L., Pai, Rish K., Shi, Qian, Alberts, Steven R., Gray, Victoria, West, Hannah D., Escott-Price, Valentina, Dunlop, Malcolm G., Cheadle, Jeremy P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - mortality Biomarkers Biomarkers, Tumor - genetics Cancer Clinical trials Colon Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - mortality Confidence intervals Diagnosis ErbB-2 protein Genome-Wide Association Study Genomes Genotype GWAS Humans Kinases Nucleotides Patients Polymorphism, Single Nucleotide Prognostic biomarkers Protein-tyrosine kinase receptors Receptor, ErbB-4 - genetics Sensitivity analysis Single-nucleotide polymorphism Survival Survival analysis Tyrosine
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Zusammenfassung:	While genome-wide association studies (GWAS) have identified germline variants influencing the risk of developing colorectal cancer (CRC), there has been limited examination of the possible role of inherited variation as a determinant of patient outcome. We performed a GWAS for overall survival (OS) in 1926 patients with advanced CRC from the COIN and COIN-B clinical trials. For single nucleotide polymorphisms (SNPs) showing an association with OS (P
ISSN:	0959-8049 1879-0852
DOI:	10.1016/j.ejca.2021.09.047