Antagonistic activity and mode of action of trypacidin from marine-derived Aspergillus fumigatus against Vibrio parahaemolyticus

This study aimed to investigate the antagonistic activity and mode of action of trypacidin from marine-derived Aspergillus fumigatus against Vibrio parahaemolyticus . Results indicated that the minimal inhibitory concentration and minimal bactericidal concentration of trypacidin against V. parahaemo...

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Veröffentlicht in:	3 Biotech 2022-06, Vol.12 (6), p.131-131, Article 131
Hauptverfasser:	Guo, Siya, Zhang, Zongyi, Xu, Xiaowen, Cai, Jing, Wang, Wenbin, Guo, Lei
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Antibacterial agents Antiinfectives and antibacterials Aspergillus fumigatus Bacteria Bioinformatics Biomaterials Biotechnology Cancer Research Cell membranes Cell walls Chemistry Chemistry and Materials Science Membrane permeability Original Original Article Permeability Stem Cells Streptomycin Streptomycin sulfate Vibrio parahaemolyticus Yard waste
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Zusammenfassung:	This study aimed to investigate the antagonistic activity and mode of action of trypacidin from marine-derived Aspergillus fumigatus against Vibrio parahaemolyticus . Results indicated that the minimal inhibitory concentration and minimal bactericidal concentration of trypacidin against V. parahaemolyticus were 31.25 and 62.5 μg/mL, respectively, which was better than that of streptomycin sulfate. Trypacidin remarkably inhibited the growth of V. parahaemolyticus and had a strong destructive effect on cell wall permeability and integrity, cell membrane permeability, and morphological alterations. Its potential as an antibacterial agent for aquatic products must be further explored.
ISSN:	2190-572X 2190-5738
DOI:	10.1007/s13205-022-03194-3