Wound healing and anti-inflammatory effects of bacterial cellulose coated with Pistacia atlantica fruit oil
Background Biological activities of Pistacia atlantica have been investigated for few decades. The fruit oil of the plant has been used for treatment of wounds, inflammation, and other ailments in Traditional Persian Medicine (TPM). Objectives The main objectives of this study were to analyze the ch...
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Veröffentlicht in: | Daru 2022-06, Vol.30 (1), p.1-10 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Background
Biological activities of
Pistacia atlantica
have been investigated for few decades. The fruit oil of the plant has been used for treatment of wounds, inflammation, and other ailments in Traditional Persian Medicine (TPM).
Objectives
The main objectives of this study were to analyze the chemical composition of
Pistacia atlantica
fruit oil and to study wound healing and anti-inflammatory effects of oil-absorbed bacterial cellulose in an in vivo burn wound model.
Method
Bacterial cellulose membrane was prepared from Kombucha culture and Fourier-transform infrared was used to characterize the bacterial cellulose. Cold press technique was used to obtain
Pistacia atlantica
fruit oil and the chemical composition was analyzed by gas chromatography. Bacterial cellulose membrane was impregnated with the
Pistacia atlantica
fruit oil.
Pistacia atlantica
hydrogel was prepared using specific Carbopol. Burn wound model was used to evaluate in vivo wound healing and anti-inflammatory effects of the wound dressings containing either silver sulfadiazine as positive control,
Pistacia atlantica
hydrogel or bacterial cellulose membrane coated with the
Pistacia atlantica
fruit oil. Blank dressing was used as negative control.
Results
FT-IR analysis showed that the structure of the bacterial cellulose corresponded with the standard FT-IR spectrum. The major components of
Pistacia atlantica
fruit oil constituted linoleic acid (38.1%), oleic acid (36.9%) and stearic acid (3.8%). Histological analysis showed that bacterial cellulose coated with fruit oil significantly decreased the number of neutrophils as a measure of inflammation compared to either negative control or positive control (p |
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ISSN: | 2008-2231 1560-8115 2008-2231 |
DOI: | 10.1007/s40199-021-00405-9 |