Decreased fatty acids induced granulosa cell apoptosis in patients with diminished ovarian reserve

Decreased fatty acids induced granulosa cell apoptosis in patients with diminished ovarian reserve

Purpose To investigate whether fatty acid changes in granulosa cells (GCs) underly the pathogenic mechanisms of diminished ovarian reserve (DOR). Methods GCs were obtained from patients with DOR ( n  = 70) and normal ovarian reserve (NOR, n  = 70). Analysis of fatty acids changes in GCs was then ana...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of assisted reproduction and genetics 2022-05, Vol.39 (5), p.1105-1114
Hauptverfasser: Zhao, Zhongying, Fan, Qigang, Zhu, Qinying, He, Ruifen, Li, Yi, Liu, Chang, Wang, Jing, Liang, Xiaolei
Format: Artikel
Sprache:eng
Schlagworte:
Adenosine Triphosphate - metabolism
Apoptosis
Apoptosis - genetics
Deoxyribonucleic acid
DNA
DNA damage
DNA repair
Fatty acids
Fatty Acids - metabolism
Female
Follicle-stimulating hormone
Granulosa cells
Granulosa Cells - metabolism
Gynecology
Human Genetics
Humans
Medicine
Medicine & Public Health
Membrane potential
Mitochondria
Ovarian Diseases - metabolism
Ovarian Reserve - genetics
Ovaries
Oxidation
Reproductive Medicine
Reproductive Physiology and Disease
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Purpose To investigate whether fatty acid changes in granulosa cells (GCs) underly the pathogenic mechanisms of diminished ovarian reserve (DOR). Methods GCs were obtained from patients with DOR ( n  = 70) and normal ovarian reserve (NOR, n  = 70). Analysis of fatty acids changes in GCs was then analyzed. Results Patients with DOR had significantly lower levels of antral follicle count and anti-Mullerian hormone and higher levels of follicle-stimulating hormone compared with NOR patients ( P  
ISSN:1058-0468
1573-7330
DOI:10.1007/s10815-022-02462-8