Standing Watch: Immune Activation and Failure in Melanoma Sentinel Lymph Nodes

An unbiased approach to map the sentinel lymph node landscape reveals progressive immune dysfunction associated with micrometastasis in patients with stage I-III cutaneous melanoma. Evidence of tumor-induced lymph node dysfunction may motivate new hypotheses for neoadjuvant therapy with potential to...

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Veröffentlicht in:	Clinical cancer research 2022-05, Vol.28 (10), p.1996-1998
1. Verfasser:	Lund, Amanda W
Format:	Artikel
Sprache:	eng
Schlagworte:	Humans Immune Tolerance Lymph Nodes - pathology Lymphatic Metastasis - pathology Melanoma - pathology Melanoma, Cutaneous Malignant Sentinel Lymph Node - pathology Skin Neoplasms - pathology Tumor Microenvironment
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Zusammenfassung:	An unbiased approach to map the sentinel lymph node landscape reveals progressive immune dysfunction associated with micrometastasis in patients with stage I-III cutaneous melanoma. Evidence of tumor-induced lymph node dysfunction may motivate new hypotheses for neoadjuvant therapy with potential to reinvigorate endogenous antitumor immunity. See related article by Yaddanapudi et al., p. 2069.
ISSN:	1078-0432 1557-3265
DOI:	10.1158/1078-0432.CCR-22-0214