21-Gene Assay to Inform Chemotherapy Benefit in Node-Positive Breast Cancer
Five-year invasive disease–free survival was similar among postmenopausal women with hormone-receptor–positive, HER2-negative breast cancer, one to three positive axillary lymph nodes, and a 21-gene recurrence score of 25 or lower who received endocrine-only therapy and those who received chemoendoc...
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| Veröffentlicht in: | The New England journal of medicine 2021-12, Vol.385 (25), p.2336-2347 |
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| container_title | The New England journal of medicine |
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| creator | Kalinsky, Kevin Barlow, William E Gralow, Julie R Meric-Bernstam, Funda Albain, Kathy S Hayes, Daniel F Lin, Nancy U Perez, Edith A Goldstein, Lori J Chia, Stephen K.L Dhesy-Thind, Sukhbinder Rastogi, Priya Alba, Emilio Delaloge, Suzette Martin, Miguel Kelly, Catherine M Ruiz-Borrego, Manuel Gil-Gil, Miguel Arce-Salinas, Claudia H Brain, Etienne G.C Lee, Eun-Sook Pierga, Jean-Yves Bermejo, Begoña Ramos-Vazquez, Manuel Jung, Kyung-Hae Ferrero, Jean-Marc Schott, Anne F Shak, Steven Sharma, Priyanka Lew, Danika L Miao, Jieling Tripathy, Debasish Pusztai, Lajos Hortobagyi, Gabriel N |
| description | Five-year invasive disease–free survival was similar among postmenopausal women with hormone-receptor–positive, HER2-negative breast cancer, one to three positive axillary lymph nodes, and a 21-gene recurrence score of 25 or lower who received endocrine-only therapy and those who received chemoendocrine therapy. In premenopausal women, chemoendocrine therapy significantly improved outcomes. |
| doi_str_mv | 10.1056/NEJMoa2108873 |
| format | Article |
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In premenopausal women, chemoendocrine therapy significantly improved outcomes.</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa2108873</identifier><identifier>PMID: 34914339</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Adult ; Age ; Aged ; Antineoplastic Agents, Hormonal - therapeutic use ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biopsy ; Breast Cancer ; Breast Neoplasms - drug therapy ; Breast Neoplasms - genetics ; Breast Neoplasms - surgery ; Cancer therapies ; Chemotherapy ; Chemotherapy, Adjuvant ; Consent ; Disease-Free Survival ; Endocrine therapy ; Epidermal growth factor ; ErbB-2 protein ; Female ; Gene Expression Profiling ; Hematology ; Humans ; Invasiveness ; Lymph nodes ; Lymphatic Metastasis ; Medical prognosis ; Menopause ; Menstruation ; Middle Aged ; Neoplasm Recurrence, Local - genetics ; Oncology ; Population ; Post-menopause ; Postmenopause ; Premenopause ; Prospective Studies ; Receptor, ErbB-2 ; Receptors, Steroid ; Reverse Transcriptase Polymerase Chain Reaction ; Survival ; Treatments in Oncology ; Womens health</subject><ispartof>The New England journal of medicine, 2021-12, Vol.385 (25), p.2336-2347</ispartof><rights>Copyright © 2021 Massachusetts Medical Society. All rights reserved.</rights><rights>Copyright © 2021 Massachusetts Medical Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c555t-8090983b4c866f7f9dcbbcebcc6c87ce55e1c22e85d9e44672c1c5b53df9c06e3</citedby><cites>FETCH-LOGICAL-c555t-8090983b4c866f7f9dcbbcebcc6c87ce55e1c22e85d9e44672c1c5b53df9c06e3</cites><orcidid>0000-0002-4873-4412 ; 0000-0001-9237-3231</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa2108873$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMoa2108873$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>230,314,776,780,881,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34914339$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kalinsky, Kevin</creatorcontrib><creatorcontrib>Barlow, William E</creatorcontrib><creatorcontrib>Gralow, Julie R</creatorcontrib><creatorcontrib>Meric-Bernstam, Funda</creatorcontrib><creatorcontrib>Albain, Kathy S</creatorcontrib><creatorcontrib>Hayes, Daniel F</creatorcontrib><creatorcontrib>Lin, Nancy U</creatorcontrib><creatorcontrib>Perez, Edith A</creatorcontrib><creatorcontrib>Goldstein, Lori J</creatorcontrib><creatorcontrib>Chia, Stephen K.L</creatorcontrib><creatorcontrib>Dhesy-Thind, Sukhbinder</creatorcontrib><creatorcontrib>Rastogi, Priya</creatorcontrib><creatorcontrib>Alba, Emilio</creatorcontrib><creatorcontrib>Delaloge, Suzette</creatorcontrib><creatorcontrib>Martin, Miguel</creatorcontrib><creatorcontrib>Kelly, Catherine M</creatorcontrib><creatorcontrib>Ruiz-Borrego, Manuel</creatorcontrib><creatorcontrib>Gil-Gil, Miguel</creatorcontrib><creatorcontrib>Arce-Salinas, Claudia H</creatorcontrib><creatorcontrib>Brain, Etienne G.C</creatorcontrib><creatorcontrib>Lee, Eun-Sook</creatorcontrib><creatorcontrib>Pierga, Jean-Yves</creatorcontrib><creatorcontrib>Bermejo, Begoña</creatorcontrib><creatorcontrib>Ramos-Vazquez, Manuel</creatorcontrib><creatorcontrib>Jung, Kyung-Hae</creatorcontrib><creatorcontrib>Ferrero, Jean-Marc</creatorcontrib><creatorcontrib>Schott, Anne F</creatorcontrib><creatorcontrib>Shak, Steven</creatorcontrib><creatorcontrib>Sharma, Priyanka</creatorcontrib><creatorcontrib>Lew, Danika L</creatorcontrib><creatorcontrib>Miao, Jieling</creatorcontrib><creatorcontrib>Tripathy, Debasish</creatorcontrib><creatorcontrib>Pusztai, Lajos</creatorcontrib><creatorcontrib>Hortobagyi, Gabriel N</creatorcontrib><title>21-Gene Assay to Inform Chemotherapy Benefit in Node-Positive Breast Cancer</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Five-year invasive disease–free survival was similar among postmenopausal women with hormone-receptor–positive, HER2-negative breast cancer, one to three positive axillary lymph nodes, and a 21-gene recurrence score of 25 or lower who received endocrine-only therapy and those who received chemoendocrine therapy. 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| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2021-12, Vol.385 (25), p.2336-2347 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9096864 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Adult Age Aged Antineoplastic Agents, Hormonal - therapeutic use Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biopsy Breast Cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - surgery Cancer therapies Chemotherapy Chemotherapy, Adjuvant Consent Disease-Free Survival Endocrine therapy Epidermal growth factor ErbB-2 protein Female Gene Expression Profiling Hematology Humans Invasiveness Lymph nodes Lymphatic Metastasis Medical prognosis Menopause Menstruation Middle Aged Neoplasm Recurrence, Local - genetics Oncology Population Post-menopause Postmenopause Premenopause Prospective Studies Receptor, ErbB-2 Receptors, Steroid Reverse Transcriptase Polymerase Chain Reaction Survival Treatments in Oncology Womens health |
| title | 21-Gene Assay to Inform Chemotherapy Benefit in Node-Positive Breast Cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T09%3A18%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=21-Gene%20Assay%20to%20Inform%20Chemotherapy%20Benefit%20in%20Node-Positive%20Breast%20Cancer&rft.jtitle=The%20New%20England%20journal%20of%20medicine&rft.au=Kalinsky,%20Kevin&rft.date=2021-12-16&rft.volume=385&rft.issue=25&rft.spage=2336&rft.epage=2347&rft.pages=2336-2347&rft.issn=0028-4793&rft.eissn=1533-4406&rft_id=info:doi/10.1056/NEJMoa2108873&rft_dat=%3Cproquest_pubme%3E2610520214%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2610520214&rft_id=info:pmid/34914339&rfr_iscdi=true |