21-Gene Assay to Inform Chemotherapy Benefit in Node-Positive Breast Cancer

Five-year invasive disease–free survival was similar among postmenopausal women with hormone-receptor–positive, HER2-negative breast cancer, one to three positive axillary lymph nodes, and a 21-gene recurrence score of 25 or lower who received endocrine-only therapy and those who received chemoendoc...

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Veröffentlicht in:	The New England journal of medicine 2021-12, Vol.385 (25), p.2336-2347
Hauptverfasser:	Kalinsky, Kevin, Barlow, William E, Gralow, Julie R, Meric-Bernstam, Funda, Albain, Kathy S, Hayes, Daniel F, Lin, Nancy U, Perez, Edith A, Goldstein, Lori J, Chia, Stephen K.L, Dhesy-Thind, Sukhbinder, Rastogi, Priya, Alba, Emilio, Delaloge, Suzette, Martin, Miguel, Kelly, Catherine M, Ruiz-Borrego, Manuel, Gil-Gil, Miguel, Arce-Salinas, Claudia H, Brain, Etienne G.C, Lee, Eun-Sook, Pierga, Jean-Yves, Bermejo, Begoña, Ramos-Vazquez, Manuel, Jung, Kyung-Hae, Ferrero, Jean-Marc, Schott, Anne F, Shak, Steven, Sharma, Priyanka, Lew, Danika L, Miao, Jieling, Tripathy, Debasish, Pusztai, Lajos, Hortobagyi, Gabriel N
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Aged Antineoplastic Agents, Hormonal - therapeutic use Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biopsy Breast Cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - surgery Cancer therapies Chemotherapy Chemotherapy, Adjuvant Consent Disease-Free Survival Endocrine therapy Epidermal growth factor ErbB-2 protein Female Gene Expression Profiling Hematology Humans Invasiveness Lymph nodes Lymphatic Metastasis Medical prognosis Menopause Menstruation Middle Aged Neoplasm Recurrence, Local - genetics Oncology Population Post-menopause Postmenopause Premenopause Prospective Studies Receptor, ErbB-2 Receptors, Steroid Reverse Transcriptase Polymerase Chain Reaction Survival Treatments in Oncology Womens health
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Beschreibung
Zusammenfassung:	Five-year invasive disease–free survival was similar among postmenopausal women with hormone-receptor–positive, HER2-negative breast cancer, one to three positive axillary lymph nodes, and a 21-gene recurrence score of 25 or lower who received endocrine-only therapy and those who received chemoendocrine therapy. In premenopausal women, chemoendocrine therapy significantly improved outcomes.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2108873