Amberlite-15 promoted an unprecedented aza Michael rearrangement for one pot synthesis of dihydroquinazolinone compounds

A new one pot multicomponent annulation strategy for the synthesis of various dihydroquinazolinone compounds has been developed using Amberlite-15 as a catalyst, giving good to moderate yields. In this reaction the substrate scope for amines and aldehydes was also investigated. The reaction has been...

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Veröffentlicht in:RSC advances 2018-01, Vol.8 (40), p.22331-22334
Hauptverfasser: Murthy, V Narayana, Nikumbh, Satish P, Tadiparthi, Krishnaji, Madhubabu, M V, Jammula, Subba Rao, Rao, L Vaikunta, Raghunadh, Akula
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Sprache:eng
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Zusammenfassung:A new one pot multicomponent annulation strategy for the synthesis of various dihydroquinazolinone compounds has been developed using Amberlite-15 as a catalyst, giving good to moderate yields. In this reaction the substrate scope for amines and aldehydes was also investigated. The reaction has been checked on a large scale and the possible reaction mechanism has also been proposed.
ISSN:2046-2069
2046-2069
DOI:10.1039/c8ra03308k