N2-selective alkylation of NH-1,2,3-triazoles with vinyl ethers via gold catalysis

N2-selective alkylation of NH-1,2,3-triazoles with vinyl ethers via gold catalysis

A new method was developed to synthesize N2-alkyl-substituted 1,2,3-triazoles via gold catalyzed alkylation of vinyl ethers with mono- and unsubstituted NH-1,2,3-triazoles and benzotriazole. A hydrogen bond between the oxygen atom of the vinyl ethers, activated via the gold catalyst, and the NH-1,2,...

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Veröffentlicht in:RSC advances 2018-08, Vol.8 (49), p.27610-27615
Hauptverfasser: Luo, Guoli, Sun, Chenyang, Li, Yan, Li, Xiaoxiao, Zhao, Zhigang
Format: Artikel
Sprache:eng
Schlagworte:
Alkylation
Benzotriazole
Catalysis
Chemical synthesis
Chemistry
Ethers
Gold
Hydrogen bonds
Triazoles
Vinyl ethers
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Beschreibung
Zusammenfassung:A new method was developed to synthesize N2-alkyl-substituted 1,2,3-triazoles via gold catalyzed alkylation of vinyl ethers with mono- and unsubstituted NH-1,2,3-triazoles and benzotriazole. A hydrogen bond between the oxygen atom of the vinyl ethers, activated via the gold catalyst, and the NH-1,2,3-triazoles was supposed to be generated, which selectively gave the N2-alkylation products.
ISSN:2046-2069
DOI:10.1039/c8ra04790a