Access to 1-amino-3,4-dihydroisoquinolines via palladium-catalyzed C-H bond aminoimidoylation reaction from functionalized isocyanides

Access to 1-amino-3,4-dihydroisoquinolines via palladium-catalyzed C-H bond aminoimidoylation reaction from functionalized isocyanides

Efficient access to 1-amino-3,4-dihydroisoquinolines, through palladium-catalyzed intramolecular C-H bond aminoimidoylation of α-benzyl-α-isocyanoacetates, has been developed. Consecutive isocyanide insertion and C-H bond activation were realized with C-N and C-C bonds formation in one step under re...

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Veröffentlicht in:RSC advances 2019-12, Vol.9 (72), p.42072-42076
Hauptverfasser: Xiong, Zhuang, Cai, Panyuan, Mei, Yingshuang, Wang, Jian
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Covalent bonds
Hydrogen bonds
Palladium
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Zusammenfassung:Efficient access to 1-amino-3,4-dihydroisoquinolines, through palladium-catalyzed intramolecular C-H bond aminoimidoylation of α-benzyl-α-isocyanoacetates, has been developed. Consecutive isocyanide insertion and C-H bond activation were realized with C-N and C-C bonds formation in one step under redox neutral conditions, employing -benzoyl hydroxylamines as electrophilic amino sources.
ISSN:2046-2069
2046-2069
DOI:10.1039/c9ra09139d