Functionalization of theranostic AGuIX® nanoparticles for PET/MRI/optical imaging

Functionalization of theranostic AGuIX® nanoparticles for PET/MRI/optical imaging

A novel trifunctional imaging probe containing a chelator of radiometal for PET, a NIR heptamethine cyanine dye, and a bioconjugatable handle, has been grafted onto AGuIX® nanoparticles via a Michael addition reaction. The resulting functionalized nanoparticles have been fully characterized, radiola...

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Veröffentlicht in:RSC advances 2019-08, Vol.9 (43), p.24811-24815
Hauptverfasser: Thakare, Vivek, Tran, Vu-Long, Natuzzi, Marco, Thomas, Eloïse, Moreau, Mathieu, Romieu, Anthony, Collin, Bertrand, Courteau, Alan, Vrigneaud, Jean-Marc, Louis, Cédric, Roux, Stéphane, Boschetti, Frédéric, Tillement, Olivier, Lux, François, Denat, Franck
Format: Artikel
Sprache:eng
Schlagworte:
Bioengineering
Cancer
Chemical Sciences
Chemistry
Cyanine dyes
Imaging
Life Sciences
Magnetic resonance imaging
Michael reaction
Nanoparticles
Positron emission
Radiochemistry
Tomography
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Beschreibung
Zusammenfassung:A novel trifunctional imaging probe containing a chelator of radiometal for PET, a NIR heptamethine cyanine dye, and a bioconjugatable handle, has been grafted onto AGuIX® nanoparticles via a Michael addition reaction. The resulting functionalized nanoparticles have been fully characterized, radiolabelled with 64 Cu, and evaluated in a mice TSA tumor model using multimodal (PET/MRI/optical) imaging. The controlled dual functionalization of AGuIX® nanoparticles afforded trimodal imaging (PET/MRI/fluorescence) theranostic agents.
ISSN:2046-2069
2046-2069
DOI:10.1039/c9ra00365g