Formal synthesis of (+)-lactacystin from l-serine

Formal synthesis of (+)-lactacystin from l-serine

A formal, stereocontrolled synthesis of lactacystin has been completed from -Bu l-serine, providing the key intermediate 13, also useful for the generation of a range of C-9 analogues.

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Veröffentlicht in:RSC advances 2019-09, Vol.9 (51), p.30019-30032
Hauptverfasser: Bulman Page, Philip C, Goodyear, Ross L, Chan, Yohan, Slawin, Alexandra M Z, Allin, Steven M
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Crystallography
NMR
Nuclear magnetic resonance
Synthesis
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Beschreibung
Zusammenfassung:A formal, stereocontrolled synthesis of lactacystin has been completed from -Bu l-serine, providing the key intermediate 13, also useful for the generation of a range of C-9 analogues.
ISSN:2046-2069
2046-2069
DOI:10.1039/c9ra07244f