Efficient synthesis of spirooxindolyl oxazol-2(5 H )-ones via palladium(ii)-catalyzed addition of arylboronic acids to nitriles

A versatile synthesis of spirooxindolyl oxazol-2(5 )-ones palladium(ii)-catalyzed addition of arylboronic acids to nitriles is described. A wide range of spirooxindolyl oxazol-2(5 )-ones and other spirocyclic frameworks incorporating the oxazol-2(5 )-one unit can be readily prepared in good to high...

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Veröffentlicht in:RSC advances 2019-09, Vol.9 (50), p.29424-29428
Hauptverfasser: Song, Hao, Cheng, Na, She, Li-Qin, Wu, Yi, Liao, Wei-Wei
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Sprache:eng
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Zusammenfassung:A versatile synthesis of spirooxindolyl oxazol-2(5 )-ones palladium(ii)-catalyzed addition of arylboronic acids to nitriles is described. A wide range of spirooxindolyl oxazol-2(5 )-ones and other spirocyclic frameworks incorporating the oxazol-2(5 )-one unit can be readily prepared in good to high yields under the optimal conditions.
ISSN:2046-2069
2046-2069
DOI:10.1039/c9ra07216k