Sarcoehrenbergilides D-F: cytotoxic cembrene diterpenoids from the soft coral Sarcophyton ehrenbergi

Sarcoehrenbergilides D-F: cytotoxic cembrene diterpenoids from the soft coral Sarcophyton ehrenbergi

A solvent extract of the soft coral afforded cembrene diterpenoids, sarcoehrenbergilid D-F (1-3). Chemical structures were established by modern spectroscopic techniques with absolute stereochemistries determined by circular dichroism (CD) and time-dependent density functional theory electronic CD c...

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Veröffentlicht in:RSC advances 2019-08, Vol.9 (47), p.27183-27189
Hauptverfasser: Hegazy, Mohamed-Elamir F, Mohamed, Tarik A, Elshamy, Abdelsamed I, Hamed, Ahmed R, Ibrahim, Mahmoud A A, Ohta, Shinji, Umeyama, Akemi, Paré, Paul W, Efferth, Thomas
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Colon
Density functional theory
Dichroism
NMR
Nuclear magnetic resonance
Organic chemistry
Time dependence
Toxicity
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Beschreibung
Zusammenfassung:A solvent extract of the soft coral afforded cembrene diterpenoids, sarcoehrenbergilid D-F (1-3). Chemical structures were established by modern spectroscopic techniques with absolute stereochemistries determined by circular dichroism (CD) and time-dependent density functional theory electronic CD calculations (TDDFT-ECD). Cytotoxicity activities for 1-3 were evaluated against three human cancer cell lines: lung (A549), colon (Caco-2) and liver (HepG2).
ISSN:2046-2069
2046-2069
DOI:10.1039/c9ra04158c