Abstract 132: Incidence and predictors of new onset diabetes after transplant (NODAT) in liver transplant recipients

Background: NODAT (New onset Diabetes after Transplant) is associated with multiple complications in liver transplant patients which has to be diagnosed and treated early to prevent graft failure and cardiovascular morbidity and mortality. Aims and Objectives: To know the incidence and predictors of NODAT. Methodology: This was retro-prospective study of non-Diabetic recipients who underwent Liver Transplantation at Yashoda Hospital, Secundarabad from January 2020 to May 2021. Follow-up duration was 6 months. Total 65 patients were enrolled. All the relevant data was collected and appropriate statistical tests were applied. Results: Total incidence of NODAT in our study was 29.2%. Among them 47.36% were transient NODAT and 52.67% were persistent NODAT. Factors significantly associated with occurrence of NODAT were: Type of Transplant (Living donor liver transplant v/s Deceased donor liver transplant), Donor CT LAI, Presence of IFG, Presence of Post-Operative Hyperglycemia, Pre transplant Magnesium & Immediate post-operative Magnesium level, Post-Operative Albumin, Trough Tacrolimus level At 3 Months, Tacrolimus and steroid dose at 3 months. Conclusions: NODAT is significant entity to be addressed. Robust strategy should be in place for screening of NODAT. Choosing donor with Higher CT LAI and minimizing Tacrolimus level could be effective strategy for prevention of NODAT.