Microwave assisted the short time clean synthesis of 1,3-diketones as building blocks in heterocyclic synthesis: a facile synthesis and antimicrobial evaluation of new dihydropyridine, 4H-pyrane, dihydropyridazine, pyrimidine and pyrazole derivatives
The compounds bearing naphthalene moiety can be used as medical preparations because of their wide spectrum of biological activity and low toxicity. In this study, a new series of azoles or azines were synthesized from the reaction of the key intermediate 1-(1-hydroxynaphthalen-2-yl)-3-phenylpropane...
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Veröffentlicht in: | Molecular diversity 2022-04, Vol.26 (2), p.741-755 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The compounds bearing naphthalene moiety can be used as medical preparations because of their wide spectrum of biological activity and low toxicity. In this study, a new series of azoles or azines were synthesized from the reaction of the key intermediate 1-(1-hydroxynaphthalen-2-yl)-3-phenylpropane-1,3-dione
3
with a variety of electrophilic and nucleophilic reagents under a variety of mild conditions. The chemical structures of these compounds were confirmed by various spectroscopic methods such as (IR,
1
H-NMR,
13
C-NMR, mass spectra and elemental analyses). The prepared compounds were screened in vitro for their anti-microbial activity against some species of Gram-positive bacteria
(Staphylococcus aureus
and
Bacillus subtilis)
and Gram-negative bacteria (
Escherichia coli
and
Pseudomonas aeuroginosa
). Anti-fungal activities of the compounds were tested against yeast and mycelial fungi,
Candida albicans
and
Aspergillus flavus
. The antimicrobial activity of this series was showed either weak or moderate activities.
Graphic abstract |
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ISSN: | 1381-1991 1573-501X |
DOI: | 10.1007/s11030-020-10152-9 |