Structural characterization of ginseng oligopeptides and anti-aging potency evaluation in Caenorhabditis elegans

The functions of ginseng polysaccharide have been widely explored, yet, the antiaging activity of ginseng oligopeptides (GOPs) has not been well explored. In the current study, seven novel GOPs were isolated, and their antiaging activity was explored in a ( ) model. Of interest, all the GOPs showed lifespan extending effects in models. Out of the GOPs treatments, 0.75 mM GOP-1 (EHGEYE) prolonged the N2 nematodes lifespan by 42.5%. Additionally, GOP-1 had a strong free radical-scavenging activity, and up-regulated the survival of the N2 under oxidative and thermal stresses. Further study revealed that GOP-1 up-regulated the transcription factor and expressions, thus we inferred that GOP-1 promotes the lifespan and stress resistances through a JNK-1-DAF-16 pathway. The current study revealed that the ginseng oligopeptides are potential antiaging agents.