Characterization of the structure-function relationship of a novel salt-resistant antimicrobial peptide, RR12

Characterization of the structure-function relationship of a novel salt-resistant antimicrobial peptide, RR12

Antimicrobial peptides (AMPs) are potential candidates in designing new anti-infective agents. However, many AMPs show poor bactericidal activities in physical salt and serum solutions. Here, we disclosed the structure-function relationships of a novel salt-resistant antimicrobial peptide, RR12, whi...

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Veröffentlicht in:RSC advances 2020-06, Vol.10 (40), p.23624-23631
Hauptverfasser: Wu, Ping-Sheng, Lai, Shu-Jung, Fung, Kit-Man, Tseng, Tien-Sheng
Format: Artikel
Sprache:eng
Schlagworte:
Antiinfectives and antibacterials
Chemistry
Peptides
Structural analysis
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Zusammenfassung:Antimicrobial peptides (AMPs) are potential candidates in designing new anti-infective agents. However, many AMPs show poor bactericidal activities in physical salt and serum solutions. Here, we disclosed the structure-function relationships of a novel salt-resistant antimicrobial peptide, RR12, which could further explain its mode of action and show its applicability in developing new antibacterial agents.
ISSN:2046-2069
2046-2069
DOI:10.1039/d0ra04299d