Vaccine-Preventable Disease Incidence Based on Clinically, Radiologically, and Etiologically Confirmed Outcomes: Systematic Literature Review and Re-analysis of Pneumococcal Conjugate Vaccine Efficacy Trials

Abstract Background Vaccine regulatory decision making is based on vaccine efficacy against etiologically confirmed outcomes, which may underestimate the preventable disease burden. To quantify this underestimation, we compared vaccine-preventable disease incidence (VPDI) of clinically defined outco...

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Veröffentlicht in:	Clinical infectious diseases 2022-04, Vol.74 (8), p.1362-1371
Hauptverfasser:	Bollaerts, Kaatje, Fletcher, Mark A, Suaya, Jose A, Hanquet, Germaine, Baay, Marc, Gessner, Bradford D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Child Humans Incidence Infant Major and Commentaries Pneumococcal Infections - epidemiology Pneumococcal Infections - prevention & control Pneumococcal Vaccines Randomized Controlled Trials as Topic Vaccine Efficacy Vaccine-Preventable Diseases Vaccines, Conjugate
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