Silent hypoxia is not an identifiable characteristic in patients with COVID-19 infection

Silent hypoxia is not an identifiable characteristic in patients with COVID-19 infection

We aimed to assess whether asymptomatic (“happy”) hypoxia was an identifiable physiological phenotype of COVID-19 acute respiratory distress syndrome (ARDS), and associated with need for ICU admission. We performed an observational cohort study of all adult patients admitted with hypoxaemic respirat...

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Veröffentlicht in:Respiratory medicine 2022-06, Vol.197, p.106858-106858, Article 106858
Hauptverfasser: Plummer, Nicholas Russell, Fogarty, Andrew, Shaw, Dominick, Card, Timothy, West, Joe, Crooks, Colin
Format: Artikel
Sprache:eng
Schlagworte:
ARDS
Clinical deterioration
COVID-19
COVID-19 - complications
Humans
Hypoxaemia
Hypoxia - etiology
Original Research
Respiratory Distress Syndrome - etiology
Respiratory Insufficiency - complications
SARS-CoV-2
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Zusammenfassung:We aimed to assess whether asymptomatic (“happy”) hypoxia was an identifiable physiological phenotype of COVID-19 acute respiratory distress syndrome (ARDS), and associated with need for ICU admission. We performed an observational cohort study of all adult patients admitted with hypoxaemic respiratory failure to a large acute hospital Trust serving the East Midlands, UK. Patients with confirmed COVID-19 were compared to those without. Physiological response to hypoxaemia was modelled using a linear mixed effects model. Of 1,586 patients included, 75% tested positive for SARS-CoV-2. The ROX index was 2.08 min−1 lower (1.56–2.61, p 
ISSN:0954-6111
1532-3064
DOI:10.1016/j.rmed.2022.106858