Heart Failure, Precision Medicine, and Incremental Equity: The Case of Hereditary Amyloid Cardiomyopathy

Echols and Taylor discuss hereditary amyloid cardiomyopathy. Heart failure is a complex clinical syndrome associated with frequently debilitating and lethal outcomes. Continual advancement in understanding the varied etiologies and specific molecular and mechanical processes underlying heart failure have led to lifesaving advances in the management of this disorder; however, the annual morbidity, mortality, and economic costs related to heart failure remain unacceptably high. Improved care options, including the precise targeting of specific physiological derangements that underlie heart failure pathology, offer hope for an improved outlook for patients.