Selective oxidation of alcohol-d1 to aldehyde-d1 using MnO2

Selective oxidation of alcohol-d1 to aldehyde-d1 using MnO2

The selective oxidation of alcohol-d1 to prepare aldehyde-d1 was newly developed by means of NaBD4 reduction/activated MnO2 oxidation. Various aldehyde-d1 derivatives including aromatic and unsaturated aldehyde-d1 can be prepared with a high deuterium incorporation ratio (up to 98% D). Halogens (chl...

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Veröffentlicht in:RSC advances 2021-01, Vol.11 (46), p.28530-28534
Hauptverfasser: Okamura, Hironori, Yasuno, Yoko, Nakayama, Atsushi, Kumadaki, Katsushi, Kitsuwa, Kohei, Ozawa, Keita, Tamura, Yusaku, Yamamoto, Yuki, Shinada, Tetsuro
Format: Artikel
Sprache:eng
Schlagworte:
Aldehydes
Alkynes
Chemistry
Cyano groups
Deuterium
Halogens
Manganese dioxide
Oxidation
Substrates
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Beschreibung
Zusammenfassung:The selective oxidation of alcohol-d1 to prepare aldehyde-d1 was newly developed by means of NaBD4 reduction/activated MnO2 oxidation. Various aldehyde-d1 derivatives including aromatic and unsaturated aldehyde-d1 can be prepared with a high deuterium incorporation ratio (up to 98% D). Halogens (chloride, bromide, and iodide), alkene, alkyne, ester, nitro, and cyano groups in the substrates are tolerated under the mild conditions.
ISSN:2046-2069
DOI:10.1039/d1ra05405h