A facile method for Rh-catalyzed decarbonylative ortho -C-H alkylation of (hetero)arenes with alkyl carboxylic acids

A facile method for Rh-catalyzed decarbonylative ortho -C-H alkylation of (hetero)arenes with alkyl carboxylic acids

A facile and effective method for Rh-catalyzed direct -alkylation of C-H bonds in (hetero)arenes with commercially available carboxylic acids has been developed. This strategy was initiated by conversion of carboxylic acids to anhydrides which, without isolation, underwent Rh-catalyzed direct decarb...

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Veröffentlicht in:RSC advances 2021-06, Vol.11 (32), p.19827-19831
Hauptverfasser: Tian, Yiqiang, Liu, Xiaojie, He, Bangyue, Ren, Yuxi, Su, Weiping
Format: Artikel
Sprache:eng
Schlagworte:
Alkylation
Aminoquinolines
Aromatic compounds
Carboxylic acids
Chemistry
Cross coupling
Functional groups
Regioselectivity
Substrates
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Beschreibung
Zusammenfassung:A facile and effective method for Rh-catalyzed direct -alkylation of C-H bonds in (hetero)arenes with commercially available carboxylic acids has been developed. This strategy was initiated by conversion of carboxylic acids to anhydrides which, without isolation, underwent Rh-catalyzed direct decarbonylative cross-coupling of aryl carboxamides containing 8-aminoquinoline. The reaction proceeds with high regioselectivity and exhibits a broad substrate scope as well as functional group tolerance.
ISSN:2046-2069
2046-2069
DOI:10.1039/d1ra03992j