SHV-14, a novel β-lactamase variant in Klebsiella pneumoniae isolates from Nijmegen, The Netherlands
Four ceftazidime-resistant isolates of a Klebsiella pneumoniae strain were collected from intensive care unit patients in Nijmegen, The Netherlands. These isolates had TEM-29 and SHV-14 beta-lactamases. SHV-14 is a novel variant, with two substitutions compared with the sequence of SHV-1: Ile8Phe an...
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| Veröffentlicht in: | Antimicrobial agents and chemotherapy 2001, Vol.45 (1), p.309-311 |
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| container_title | Antimicrobial agents and chemotherapy |
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| creator | MEIFANG YUAN HALL, Lucinda M. C HOOGKAMP-KORSTANJE, Jaa LIVERMORE, David M |
| description | Four ceftazidime-resistant isolates of a Klebsiella pneumoniae strain were collected from intensive care unit patients in Nijmegen, The Netherlands. These isolates had TEM-29 and SHV-14 beta-lactamases. SHV-14 is a novel variant, with two substitutions compared with the sequence of SHV-1: Ile8Phe and Arg43Ser. Its gene also had a silent C-->T mutation at nucleotide 481. The SHV-14 enzyme had slightly higher V(max) rates than SHV-1 for oxyimino-aminothiazolyl cephalosporins, but this activity was insufficient for the enzyme to count as an extended-spectrum beta-lactamase. |
| doi_str_mv | 10.1128/AAC.45.1.309-311.2001 |
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Enzymes ; Microbial Sensitivity Tests ; Microbiology ; Molecular Sequence Data ; Netherlands ; Netherlands, Nijmegen ; Plasmids - genetics ; SHV-14 protein</subject><ispartof>Antimicrobial agents and chemotherapy, 2001, Vol.45 (1), p.309-311</ispartof><rights>2001 INIST-CNRS</rights><rights>Copyright © 2001, American Society for Microbiology 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-89ee2442f22c84fcaff88476c7ed5d1f8bd72120cbff479bef53c052615b77673</citedby><cites>FETCH-LOGICAL-c464t-89ee2442f22c84fcaff88476c7ed5d1f8bd72120cbff479bef53c052615b77673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC90280/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC90280/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=912119$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11120985$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MEIFANG YUAN</creatorcontrib><creatorcontrib>HALL, Lucinda M. C</creatorcontrib><creatorcontrib>HOOGKAMP-KORSTANJE, Jaa</creatorcontrib><creatorcontrib>LIVERMORE, David M</creatorcontrib><title>SHV-14, a novel β-lactamase variant in Klebsiella pneumoniae isolates from Nijmegen, The Netherlands</title><title>Antimicrobial agents and chemotherapy</title><addtitle>Antimicrob Agents Chemother</addtitle><description>Four ceftazidime-resistant isolates of a Klebsiella pneumoniae strain were collected from intensive care unit patients in Nijmegen, The Netherlands. These isolates had TEM-29 and SHV-14 beta-lactamases. SHV-14 is a novel variant, with two substitutions compared with the sequence of SHV-1: Ile8Phe and Arg43Ser. Its gene also had a silent C-->T mutation at nucleotide 481. The SHV-14 enzyme had slightly higher V(max) rates than SHV-1 for oxyimino-aminothiazolyl cephalosporins, but this activity was insufficient for the enzyme to count as an extended-spectrum beta-lactamase.</description><subject>Bacteriology</subject><subject>beta-Lactamases - genetics</subject><subject>beta-Lactamases - isolation & purification</subject><subject>beta-Lactamases - metabolism</subject><subject>Biological and medical sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Kinetics</subject><subject>Klebsiella Infections - microbiology</subject><subject>Klebsiella pneumoniae</subject><subject>Klebsiella pneumoniae - drug effects</subject><subject>Klebsiella pneumoniae - enzymology</subject><subject>Klebsiella pneumoniae - genetics</subject><subject>Mechanisms of Resistance</subject><subject>Metabolism. Enzymes</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbiology</subject><subject>Molecular Sequence Data</subject><subject>Netherlands</subject><subject>Netherlands, Nijmegen</subject><subject>Plasmids - genetics</subject><subject>SHV-14 protein</subject><issn>0066-4804</issn><issn>1098-6596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkdFqFDEUhoModq0-ghIQetUZk0wyyYA3y6KttNQLq7chkznppmQyazK74Gv1QfpMzdKl1is5F-GQ7z-cw4fQe0pqSpn6tFyuai5qWjekqxpKa0YIfYEWlHSqakXXvkQLQtq24orwI_Qm51tSetGR1-iIlhGFEwsEP85_VZSfYoPjtIOA7--qYOxsRpMB70zyJs7YR3wRoM8eQjB4E2E7TtEbwD5PwcyQsUvTiK_87Qg3EE_x9RrwFcxrSMHEIb9Fr5wJGd4d3mP08-uX69V5dfn97NtqeVlZ3vK5Uh0A45w5xqzizhrnlOKytRIGMVCn-kGysrntneOy68GJxhLBWip6KVvZHKPPj3M3236EwUKckwl6k_xo0h89Ga___Yl-rW-mne4IU6TETw7xNP3eQp716LPd3xxh2mYtieClmv-CVEohOBEFFI-gTVPOCdzTLpTovUddPGouNNXFoy4e9d5jyX14fsjf1EFcAT4eAJOtCS6ZaH1-4jrKKO2aB9oHp2o</recordid><startdate>2001</startdate><enddate>2001</enddate><creator>MEIFANG YUAN</creator><creator>HALL, Lucinda M. C</creator><creator>HOOGKAMP-KORSTANJE, Jaa</creator><creator>LIVERMORE, David M</creator><general>American Society for Microbiology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2001</creationdate><title>SHV-14, a novel β-lactamase variant in Klebsiella pneumoniae isolates from Nijmegen, The Netherlands</title><author>MEIFANG YUAN ; HALL, Lucinda M. C ; HOOGKAMP-KORSTANJE, Jaa ; LIVERMORE, David M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-89ee2442f22c84fcaff88476c7ed5d1f8bd72120cbff479bef53c052615b77673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Bacteriology</topic><topic>beta-Lactamases - genetics</topic><topic>beta-Lactamases - isolation & purification</topic><topic>beta-Lactamases - metabolism</topic><topic>Biological and medical sciences</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Kinetics</topic><topic>Klebsiella Infections - microbiology</topic><topic>Klebsiella pneumoniae</topic><topic>Klebsiella pneumoniae - drug effects</topic><topic>Klebsiella pneumoniae - enzymology</topic><topic>Klebsiella pneumoniae - genetics</topic><topic>Mechanisms of Resistance</topic><topic>Metabolism. 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| subjects | Bacteriology beta-Lactamases - genetics beta-Lactamases - isolation & purification beta-Lactamases - metabolism Biological and medical sciences Fundamental and applied biological sciences. Psychology Kinetics Klebsiella Infections - microbiology Klebsiella pneumoniae Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - enzymology Klebsiella pneumoniae - genetics Mechanisms of Resistance Metabolism. Enzymes Microbial Sensitivity Tests Microbiology Molecular Sequence Data Netherlands Netherlands, Nijmegen Plasmids - genetics SHV-14 protein |
| title | SHV-14, a novel β-lactamase variant in Klebsiella pneumoniae isolates from Nijmegen, The Netherlands |
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