Arsenic, cadmium, and selenium exposures and bone mineral density-related endpoints: The HORTEGA study
Experimental data suggest that trace elements, such as arsenic (As), cadmium (Cd), and selenium (Se) can influence the bone remodeling process. We evaluated the cross-sectional association between As, Cd, and Se biomarkers with bone mineral density (BMD) measured at the calcaneus, in a representativ...
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| Veröffentlicht in: | Free radical biology & medicine 2021-01, Vol.162, p.392-400 |
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| creator | Galvez-Fernandez, Marta Grau-Perez, Maria Garcia-Barrera, Tamara Ramirez-Acosta, Sara Gomez-Ariza, Jose L. Perez-Gomez, Beatriz Galan-Labaca, Iñaki Navas-Acien, Ana Redon, Josep Briongos-Figuero, Laisa S. Dueñas-Laita, Antonio Perez-Castrillon, Jose Luis Tellez-Plaza, Maria Martin-Escudero, Juan Carlos |
| description | Experimental data suggest that trace elements, such as arsenic (As), cadmium (Cd), and selenium (Se) can influence the bone remodeling process. We evaluated the cross-sectional association between As, Cd, and Se biomarkers with bone mineral density (BMD) measured at the calcaneus, in a representative sample of a general population from Spain. As secondary analyses we evaluated the associations of interest in subgroups defined by well-established BMD determinants, and also conducted prospective analysis of osteoporosis-related incident bone fractures restricted to participants older than 50 years-old.
In N = 1365 Hortega Study participants >20 years-old, urine As and Cd were measured by inductively coupled-plasma mass spectrometry (ICPMS); plasma Se was measured by atomic absorption spectrometry (AAS) with graphite furnace; and BMD at the calcaneus was measured using the Peripheral Instaneuous X-ray Imaging system (PIXI). As levels were corrected for arsenobetaine (Asb) to account for inorganic As exposure.
The median of total urine As, Asb-corrected urine As, urine Cd, and plasma Se was 61.3, 6.53 and 0.39 μg/g creatinine, and 84.9 μg/L, respectively. In cross-sectional analysis, urine As and Cd were not associated with reduced BMD (T-score 105 μg/L was positively associated with fracture risk |
| doi_str_mv | 10.1016/j.freeradbiomed.2020.10.318 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9019194</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0891584920315926</els_id><sourcerecordid>2457281087</sourcerecordid><originalsourceid>FETCH-LOGICAL-c491t-b9f9de0ba8ad081384444030bbadfc128cc11eff0e7e3f3e41438733a7af0bba3</originalsourceid><addsrcrecordid>eNqNUcFqGzEQFaWhcdz-QhH00kPWlVayV2qhYIKbFAKB4p6FVho1MruSK-2G-u-jjdOQ3KKLYN6b92bmIfSJkgUldPVlt3AJIGnb-tiDXdSknpAFo-INmlHRsIov5eotmhEhabUUXJ6is5x3hBC-ZOIdOmWMsoav5Ay5dcoQvDnHRtvej_051sHiDF2pjj2Gf_uYxwT5odzGALj3obh32ELIfjhUCTo9gMUQ7D76MOSveHsL-Orm13ZzucZ5GO3hPTpxusvw4fGfo98_NtuLq-r65vLnxfq6MlzSoWqlkxZIq4W2RFAmeHmEkbbV1hlaC2MoBecINMAcA045K_sy3Wg3kdgcfT_q7se23MZAGMqoap98r9NBRe3VSyT4W_Un3ilJqKSSF4HPjwIp_h0hD6r32UDX6QBxzKrmy6YWlBTXOfp2pJoUc07gnmwoUVNSaqdeJKWmpCawJFW6Pz6f9Kn3fzSFsDkSoNzrzkNS2XgIBqxPYAZlo3-V0T1IWq8-</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2457281087</pqid></control><display><type>article</type><title>Arsenic, cadmium, and selenium exposures and bone mineral density-related endpoints: The HORTEGA study</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Galvez-Fernandez, Marta ; Grau-Perez, Maria ; Garcia-Barrera, Tamara ; Ramirez-Acosta, Sara ; Gomez-Ariza, Jose L. ; Perez-Gomez, Beatriz ; Galan-Labaca, Iñaki ; Navas-Acien, Ana ; Redon, Josep ; Briongos-Figuero, Laisa S. ; Dueñas-Laita, Antonio ; Perez-Castrillon, Jose Luis ; Tellez-Plaza, Maria ; Martin-Escudero, Juan Carlos</creator><creatorcontrib>Galvez-Fernandez, Marta ; Grau-Perez, Maria ; Garcia-Barrera, Tamara ; Ramirez-Acosta, Sara ; Gomez-Ariza, Jose L. ; Perez-Gomez, Beatriz ; Galan-Labaca, Iñaki ; Navas-Acien, Ana ; Redon, Josep ; Briongos-Figuero, Laisa S. ; Dueñas-Laita, Antonio ; Perez-Castrillon, Jose Luis ; Tellez-Plaza, Maria ; Martin-Escudero, Juan Carlos</creatorcontrib><description>Experimental data suggest that trace elements, such as arsenic (As), cadmium (Cd), and selenium (Se) can influence the bone remodeling process. We evaluated the cross-sectional association between As, Cd, and Se biomarkers with bone mineral density (BMD) measured at the calcaneus, in a representative sample of a general population from Spain. As secondary analyses we evaluated the associations of interest in subgroups defined by well-established BMD determinants, and also conducted prospective analysis of osteoporosis-related incident bone fractures restricted to participants older than 50 years-old.
In N = 1365 Hortega Study participants >20 years-old, urine As and Cd were measured by inductively coupled-plasma mass spectrometry (ICPMS); plasma Se was measured by atomic absorption spectrometry (AAS) with graphite furnace; and BMD at the calcaneus was measured using the Peripheral Instaneuous X-ray Imaging system (PIXI). As levels were corrected for arsenobetaine (Asb) to account for inorganic As exposure.
The median of total urine As, Asb-corrected urine As, urine Cd, and plasma Se was 61.3, 6.53 and 0.39 μg/g creatinine, and 84.9 μg/L, respectively. In cross-sectional analysis, urine As and Cd were not associated with reduced BMD (T-score < -1 SD). We observed a non-linear dose-response of Se and reduced BMD, showing an inverse association below ~105 μg/L, which became increasingly positive above ~105 μg/L. The evaluated subgroups did not show differential associations. In prospective analysis, while we also observed a U-shape dose-response of Se with the incidence of osteoporosis-related bone fractures, the positive association above ~105 μg/L was markedly stronger, compared to the cross-sectional analysis.
Our results support that Se, but not As and Cd, was associated to BMD-related disease. The association of Se and BMD-related disease was non-linear, including a strong positive association with osteoporosis-related bone fractures risk at the higher Se exposure range. Considering the substantial burden of bone loss in elderly populations, additional large prospective studies are needed to confirm the relevance of our findings to bone loss prevention in the population depending on Se exposure levels.
[Display omitted]
•Selenium (Se), not arsenic or cadmium, was associated to reduced bone mineral density (BMD).•The relation of Se with reduced BMD was non-linear and not differential by subgroups.•Se > 105 μg/L was positively associated with fracture risk among individuals >50 years.•Se may be relevant for bone loss prevention depending on the dose.</description><identifier>ISSN: 0891-5849</identifier><identifier>ISSN: 1873-4596</identifier><identifier>EISSN: 1873-4596</identifier><identifier>DOI: 10.1016/j.freeradbiomed.2020.10.318</identifier><identifier>PMID: 33137469</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Arsenic ; Arsenic - toxicity ; Bone Density ; Bone mineral density ; Cadmium ; Cadmium - toxicity ; Cross-Sectional Studies ; Humans ; Middle Aged ; Osteoporosis ; Prospective Studies ; Selenium ; Young Adult</subject><ispartof>Free radical biology & medicine, 2021-01, Vol.162, p.392-400</ispartof><rights>2020 Elsevier Inc.</rights><rights>Copyright © 2020 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-b9f9de0ba8ad081384444030bbadfc128cc11eff0e7e3f3e41438733a7af0bba3</citedby><cites>FETCH-LOGICAL-c491t-b9f9de0ba8ad081384444030bbadfc128cc11eff0e7e3f3e41438733a7af0bba3</cites><orcidid>0000-0002-3850-1228 ; 0000-0002-8859-9550</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.freeradbiomed.2020.10.318$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33137469$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Galvez-Fernandez, Marta</creatorcontrib><creatorcontrib>Grau-Perez, Maria</creatorcontrib><creatorcontrib>Garcia-Barrera, Tamara</creatorcontrib><creatorcontrib>Ramirez-Acosta, Sara</creatorcontrib><creatorcontrib>Gomez-Ariza, Jose L.</creatorcontrib><creatorcontrib>Perez-Gomez, Beatriz</creatorcontrib><creatorcontrib>Galan-Labaca, Iñaki</creatorcontrib><creatorcontrib>Navas-Acien, Ana</creatorcontrib><creatorcontrib>Redon, Josep</creatorcontrib><creatorcontrib>Briongos-Figuero, Laisa S.</creatorcontrib><creatorcontrib>Dueñas-Laita, Antonio</creatorcontrib><creatorcontrib>Perez-Castrillon, Jose Luis</creatorcontrib><creatorcontrib>Tellez-Plaza, Maria</creatorcontrib><creatorcontrib>Martin-Escudero, Juan Carlos</creatorcontrib><title>Arsenic, cadmium, and selenium exposures and bone mineral density-related endpoints: The HORTEGA study</title><title>Free radical biology & medicine</title><addtitle>Free Radic Biol Med</addtitle><description>Experimental data suggest that trace elements, such as arsenic (As), cadmium (Cd), and selenium (Se) can influence the bone remodeling process. We evaluated the cross-sectional association between As, Cd, and Se biomarkers with bone mineral density (BMD) measured at the calcaneus, in a representative sample of a general population from Spain. As secondary analyses we evaluated the associations of interest in subgroups defined by well-established BMD determinants, and also conducted prospective analysis of osteoporosis-related incident bone fractures restricted to participants older than 50 years-old.
In N = 1365 Hortega Study participants >20 years-old, urine As and Cd were measured by inductively coupled-plasma mass spectrometry (ICPMS); plasma Se was measured by atomic absorption spectrometry (AAS) with graphite furnace; and BMD at the calcaneus was measured using the Peripheral Instaneuous X-ray Imaging system (PIXI). As levels were corrected for arsenobetaine (Asb) to account for inorganic As exposure.
The median of total urine As, Asb-corrected urine As, urine Cd, and plasma Se was 61.3, 6.53 and 0.39 μg/g creatinine, and 84.9 μg/L, respectively. In cross-sectional analysis, urine As and Cd were not associated with reduced BMD (T-score < -1 SD). We observed a non-linear dose-response of Se and reduced BMD, showing an inverse association below ~105 μg/L, which became increasingly positive above ~105 μg/L. The evaluated subgroups did not show differential associations. In prospective analysis, while we also observed a U-shape dose-response of Se with the incidence of osteoporosis-related bone fractures, the positive association above ~105 μg/L was markedly stronger, compared to the cross-sectional analysis.
Our results support that Se, but not As and Cd, was associated to BMD-related disease. The association of Se and BMD-related disease was non-linear, including a strong positive association with osteoporosis-related bone fractures risk at the higher Se exposure range. Considering the substantial burden of bone loss in elderly populations, additional large prospective studies are needed to confirm the relevance of our findings to bone loss prevention in the population depending on Se exposure levels.
[Display omitted]
•Selenium (Se), not arsenic or cadmium, was associated to reduced bone mineral density (BMD).•The relation of Se with reduced BMD was non-linear and not differential by subgroups.•Se > 105 μg/L was positively associated with fracture risk among individuals >50 years.•Se may be relevant for bone loss prevention depending on the dose.</description><subject>Adult</subject><subject>Aged</subject><subject>Arsenic</subject><subject>Arsenic - toxicity</subject><subject>Bone Density</subject><subject>Bone mineral density</subject><subject>Cadmium</subject><subject>Cadmium - toxicity</subject><subject>Cross-Sectional Studies</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Osteoporosis</subject><subject>Prospective Studies</subject><subject>Selenium</subject><subject>Young Adult</subject><issn>0891-5849</issn><issn>1873-4596</issn><issn>1873-4596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUcFqGzEQFaWhcdz-QhH00kPWlVayV2qhYIKbFAKB4p6FVho1MruSK-2G-u-jjdOQ3KKLYN6b92bmIfSJkgUldPVlt3AJIGnb-tiDXdSknpAFo-INmlHRsIov5eotmhEhabUUXJ6is5x3hBC-ZOIdOmWMsoav5Ay5dcoQvDnHRtvej_051sHiDF2pjj2Gf_uYxwT5odzGALj3obh32ELIfjhUCTo9gMUQ7D76MOSveHsL-Orm13ZzucZ5GO3hPTpxusvw4fGfo98_NtuLq-r65vLnxfq6MlzSoWqlkxZIq4W2RFAmeHmEkbbV1hlaC2MoBecINMAcA045K_sy3Wg3kdgcfT_q7se23MZAGMqoap98r9NBRe3VSyT4W_Un3ilJqKSSF4HPjwIp_h0hD6r32UDX6QBxzKrmy6YWlBTXOfp2pJoUc07gnmwoUVNSaqdeJKWmpCawJFW6Pz6f9Kn3fzSFsDkSoNzrzkNS2XgIBqxPYAZlo3-V0T1IWq8-</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Galvez-Fernandez, Marta</creator><creator>Grau-Perez, Maria</creator><creator>Garcia-Barrera, Tamara</creator><creator>Ramirez-Acosta, Sara</creator><creator>Gomez-Ariza, Jose L.</creator><creator>Perez-Gomez, Beatriz</creator><creator>Galan-Labaca, Iñaki</creator><creator>Navas-Acien, Ana</creator><creator>Redon, Josep</creator><creator>Briongos-Figuero, Laisa S.</creator><creator>Dueñas-Laita, Antonio</creator><creator>Perez-Castrillon, Jose Luis</creator><creator>Tellez-Plaza, Maria</creator><creator>Martin-Escudero, Juan Carlos</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3850-1228</orcidid><orcidid>https://orcid.org/0000-0002-8859-9550</orcidid></search><sort><creationdate>20210101</creationdate><title>Arsenic, cadmium, and selenium exposures and bone mineral density-related endpoints: The HORTEGA study</title><author>Galvez-Fernandez, Marta ; 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We evaluated the cross-sectional association between As, Cd, and Se biomarkers with bone mineral density (BMD) measured at the calcaneus, in a representative sample of a general population from Spain. As secondary analyses we evaluated the associations of interest in subgroups defined by well-established BMD determinants, and also conducted prospective analysis of osteoporosis-related incident bone fractures restricted to participants older than 50 years-old.
In N = 1365 Hortega Study participants >20 years-old, urine As and Cd were measured by inductively coupled-plasma mass spectrometry (ICPMS); plasma Se was measured by atomic absorption spectrometry (AAS) with graphite furnace; and BMD at the calcaneus was measured using the Peripheral Instaneuous X-ray Imaging system (PIXI). As levels were corrected for arsenobetaine (Asb) to account for inorganic As exposure.
The median of total urine As, Asb-corrected urine As, urine Cd, and plasma Se was 61.3, 6.53 and 0.39 μg/g creatinine, and 84.9 μg/L, respectively. In cross-sectional analysis, urine As and Cd were not associated with reduced BMD (T-score < -1 SD). We observed a non-linear dose-response of Se and reduced BMD, showing an inverse association below ~105 μg/L, which became increasingly positive above ~105 μg/L. The evaluated subgroups did not show differential associations. In prospective analysis, while we also observed a U-shape dose-response of Se with the incidence of osteoporosis-related bone fractures, the positive association above ~105 μg/L was markedly stronger, compared to the cross-sectional analysis.
Our results support that Se, but not As and Cd, was associated to BMD-related disease. The association of Se and BMD-related disease was non-linear, including a strong positive association with osteoporosis-related bone fractures risk at the higher Se exposure range. Considering the substantial burden of bone loss in elderly populations, additional large prospective studies are needed to confirm the relevance of our findings to bone loss prevention in the population depending on Se exposure levels.
[Display omitted]
•Selenium (Se), not arsenic or cadmium, was associated to reduced bone mineral density (BMD).•The relation of Se with reduced BMD was non-linear and not differential by subgroups.•Se > 105 μg/L was positively associated with fracture risk among individuals >50 years.•Se may be relevant for bone loss prevention depending on the dose.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>33137469</pmid><doi>10.1016/j.freeradbiomed.2020.10.318</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-3850-1228</orcidid><orcidid>https://orcid.org/0000-0002-8859-9550</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Arsenic Arsenic - toxicity Bone Density Bone mineral density Cadmium Cadmium - toxicity Cross-Sectional Studies Humans Middle Aged Osteoporosis Prospective Studies Selenium Young Adult |
| title | Arsenic, cadmium, and selenium exposures and bone mineral density-related endpoints: The HORTEGA study |
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