Arsenic, cadmium, and selenium exposures and bone mineral density-related endpoints: The HORTEGA study

Experimental data suggest that trace elements, such as arsenic (As), cadmium (Cd), and selenium (Se) can influence the bone remodeling process. We evaluated the cross-sectional association between As, Cd, and Se biomarkers with bone mineral density (BMD) measured at the calcaneus, in a representativ...

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Veröffentlicht in:Free radical biology & medicine 2021-01, Vol.162, p.392-400
Hauptverfasser: Galvez-Fernandez, Marta, Grau-Perez, Maria, Garcia-Barrera, Tamara, Ramirez-Acosta, Sara, Gomez-Ariza, Jose L., Perez-Gomez, Beatriz, Galan-Labaca, Iñaki, Navas-Acien, Ana, Redon, Josep, Briongos-Figuero, Laisa S., Dueñas-Laita, Antonio, Perez-Castrillon, Jose Luis, Tellez-Plaza, Maria, Martin-Escudero, Juan Carlos
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Sprache:eng
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Zusammenfassung:Experimental data suggest that trace elements, such as arsenic (As), cadmium (Cd), and selenium (Se) can influence the bone remodeling process. We evaluated the cross-sectional association between As, Cd, and Se biomarkers with bone mineral density (BMD) measured at the calcaneus, in a representative sample of a general population from Spain. As secondary analyses we evaluated the associations of interest in subgroups defined by well-established BMD determinants, and also conducted prospective analysis of osteoporosis-related incident bone fractures restricted to participants older than 50 years-old. In N = 1365 Hortega Study participants >20 years-old, urine As and Cd were measured by inductively coupled-plasma mass spectrometry (ICPMS); plasma Se was measured by atomic absorption spectrometry (AAS) with graphite furnace; and BMD at the calcaneus was measured using the Peripheral Instaneuous X-ray Imaging system (PIXI). As levels were corrected for arsenobetaine (Asb) to account for inorganic As exposure. The median of total urine As, Asb-corrected urine As, urine Cd, and plasma Se was 61.3, 6.53 and 0.39 μg/g creatinine, and 84.9 μg/L, respectively. In cross-sectional analysis, urine As and Cd were not associated with reduced BMD (T-score  105 μg/L was positively associated with fracture risk
ISSN:0891-5849
1873-4596
1873-4596
DOI:10.1016/j.freeradbiomed.2020.10.318