EMBER: multi-label prediction of kinase-substrate phosphorylation events through deep learning

EMBER: multi-label prediction of kinase-substrate phosphorylation events through deep learning

Abstract Motivation Kinase-catalyzed phosphorylation of proteins forms the backbone of signal transduction within the cell, enabling the coordination of numerous processes such as the cell cycle, apoptosis, and differentiation. Although on the order of 105 phosphorylation events have been described,...

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Veröffentlicht in:Bioinformatics 2022-04, Vol.38 (8), p.2119-2126
Hauptverfasser: Kirchoff, Kathryn E, Gomez, Shawn M
Format: Artikel
Sprache:eng
Schlagworte:
Deep Learning
Original Papers
Phosphorylation
Phosphotransferases
Phylogeny
Proteins
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Zusammenfassung:Abstract Motivation Kinase-catalyzed phosphorylation of proteins forms the backbone of signal transduction within the cell, enabling the coordination of numerous processes such as the cell cycle, apoptosis, and differentiation. Although on the order of 105 phosphorylation events have been described, we know the specific kinase performing these functions for
ISSN:1367-4803
1460-2059
1367-4811
DOI:10.1093/bioinformatics/btac083