Influence of ethnicity on biochemical markers of health and disease in the CALIPER cohort of healthy children and adolescents

Background Accurate pediatric reference intervals (RIs) for laboratory tests determined in a healthy pediatric population are essential for correct laboratory test interpretation and clinical decision-making. In pediatrics, RIs require partitioning by age and/or sex; however, the need for partitioni...

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Veröffentlicht in:	Clinical chemistry and laboratory medicine 2020-03, Vol.58 (4), p.605-617
Hauptverfasser:	Tahmasebi, Houman, Asgari, Shervin, Hall, Alexandra, Higgins, Victoria, Chowdhury, Ashfia, Thompson, Rebecca, Bohn, Mary Kathryn, Macri, Joseph, Adeli, Khosrow
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adolescents Age Amylases - analysis Amylases - standards Biochemical markers Biomarkers Biomarkers - analysis CALIPER Canada Child Children Cohort Studies Databases, Factual Decision making Ethnic Groups Ethnicity Female Ferritin Follicle Stimulating Hormone - analysis Follicle Stimulating Hormone - standards Follicle-stimulating hormone Humans IgG antibody Immunoglobulin A Immunoglobulin G Immunoglobulin M Immunoglobulins Informed consent Intervals Laboratories Laboratory tests Male Minority & ethnic groups Nutrition Partitioning pediatric Pediatrics Population studies reference intervals Reference Values Reference Values and Biological Variations Retrospective Studies Sex Statistical analysis Statistical methods Statistical significance Vitamin D Vitamin D - analysis Vitamin D - standards
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Zusammenfassung:	Background Accurate pediatric reference intervals (RIs) for laboratory tests determined in a healthy pediatric population are essential for correct laboratory test interpretation and clinical decision-making. In pediatrics, RIs require partitioning by age and/or sex; however, the need for partitioning based on ethnicity is unclear. Here, we assessed the influence of ethnicity on biomarker concentrations in the Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER) cohort of healthy children and adolescents and compared the results with the National Health and Nutrition Examination Survey (NHANES). Methods A total of 52 biomarkers were measured in a multiethnic population of 846-1179 healthy children (aged 5 to
ISSN:	1434-6621 1437-4331
DOI:	10.1515/cclm-2019-0876