Multicenter Retrospective Study of Intravascular DLBCL Treated at Academic Institutions within the United States

Intravascular Diffuse Large B-Cell Lymphoma (IVLBCL) is a rare entity, with a generally aggressive course that may vary based on geographic presentation. While a United States (US) registry study showed relatively good outcomes with IVLBCL, clinicopathologic and treatment data were unavailable. We performed a detailed retrospective review of cases identified at 8 US medical centers, to improve understanding of IVLBCL and inform management. We compiled data retrieved via IRB-approved review of IVLBCL cases identified from 1999–2015 at eight academic institutions across the US. We characterized the cohort’s clinical status at time of diagnosis, presenting diagnostic and clinical features of the disease, treatment modalities used, and overall prognostic data. Our cohort consisted of 54 patients with varying degrees of clinical. Adjusting for age, better performance status at presentation was associated with increased survival time for the patients diagnosed in vivo (HR: 2.12, 95% CI 1.28, 3.53). Based on the data we have collected, it would appear that the time interval to diagnosis is a significant contributor to outcomes of patients with IVLBCL.