Evernimicin (SCH27899) inhibits both translation and 50S ribosomal subunit formation in Staphylococcus aureus cells

The effects of the everninomicin antibiotic evernimicin (SCH27899) on growing Staphylococcus aureus cells were investigated. Cellular growth rates and viable cell numbers decreased with increasing antibiotic concentrations. The rate of protein synthesis, measured as (35)S-amino acid incorporation, d...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2000-06, Vol.44 (6), p.1413-1417
Hauptverfasser:	Champney, W S, Tober, C L
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoglycosides Anti-Bacterial Agents - pharmacology Dose-Response Relationship, Drug Mechanisms of Action: Physiological Effects Ribosomal Proteins - antagonists & inhibitors Ribosomes - drug effects Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus aureus - genetics
Online-Zugang:	Volltext
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