Immunogenicity and safety of homologous and heterologous ChAdOx1-S and mRNA-1273 vaccinations in healthy adults in Taiwan

•From March to November 2021, homologous or heterologous regimens with ChAdOx1-S and mRNA-1273 vaccination (ChAdOx1-S/ChAdOx1-S, mRNA-1273/mRNA-1273, ChAdOx1-S/mRNA-1273) were given to 945 healthy participants.•Heterologous vaccination with ChAdOx1-S/mRNA-1273 had an acceptable safety profile and in...

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Veröffentlicht in:	Journal of clinical virology 2022-06, Vol.150-151, p.105156-105156, Article 105156
Hauptverfasser:	Kang, Chun-Min, Lee, Nan-Yao, Lin, Chih-Hsueh, Hsu, Yuan-Shan, Chang, Yu-Chang, Chung, Ming-Yi, Lee, Ya-Fan, Tseng, Wen-Pin, Wu, Jhong-Lin, Chen, Shey-Ying, Lu, Min-Chi, Ko, Wen-Chien, Lee, Ping-Ing, Hsueh, Po-Ren
Format:	Artikel
Sprache:	eng
Schlagworte:	2019-nCoV Vaccine mRNA-1273 - adverse effects 2019-nCoV Vaccine mRNA-1273 - immunology Adult Antibodies, Viral ChAdOx1 nCoV-19 - adverse effects ChAdOx1 nCoV-19 - immunology COVID-19 - prevention & control COVID-19 vaccines Homologous and heterologous prime-boost regimens Humans Immunogenicity Immunogenicity, Vaccine Immunoglobulin G Safety SARS-CoV-2 Taiwan Vaccination
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Zusammenfassung:	•From March to November 2021, homologous or heterologous regimens with ChAdOx1-S and mRNA-1273 vaccination (ChAdOx1-S/ChAdOx1-S, mRNA-1273/mRNA-1273, ChAdOx1-S/mRNA-1273) were given to 945 healthy participants.•Heterologous vaccination with ChAdOx1-S/mRNA-1273 had an acceptable safety profile and induced higher total anti-RBD/S1 antibody production (p
ISSN:	1386-6532 1873-5967 1873-5967
DOI:	10.1016/j.jcv.2022.105156