Impact of diabetes status on immunogenicity of trivalent inactivated influenza vaccine in older adults

Impact of diabetes status on immunogenicity of trivalent inactivated influenza vaccine in older adults

Individuals with type 2 diabetes mellitus experience high rates of influenza virus infection and complications. We compared the magnitude and duration of serologic response to trivalent influenza vaccine in adults aged 50–80 with and without type 2 diabetes mellitus. Serologic response to influenza...

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Veröffentlicht in:Influenza and other respiratory viruses 2022-05, Vol.16 (3), p.562-567
Hauptverfasser: Spencer, Sarah, Chung, Jessie R., Belongia, Edward A., Sundaram, Maria, Meece, Jennifer, Coleman, Laura A., Zimmerman, Richard K., Nowalk, Mary Patricia, Moehling Geffel, Krissy, Ross, Ted, Carter, Chalise E., Shay, David, Levine, Min, Liepkalns, Justine, Kim, Jin Hyang, Sambhara, Suryaprakash, Thompson, Mark G., Flannery, Brendan
Format: Artikel
Sprache:eng
Schlagworte:
Adults
Aged
Aged, 80 and over
Antibodies
Antibodies, Viral
Antigens
Complications
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2
Enrollments
Guillain-Barre syndrome
Hemagglutination Inhibition Tests
Humans
Immunogenicity
Influenza
Influenza A Virus, H3N2 Subtype
Influenza Vaccines
Influenza, Human - prevention & control
Laboratories
Memory
Middle Aged
Obesity
Older people
Original
Regression analysis
Respiratory diseases
serologic response
Serology
Vaccination
vaccine
Vaccines
Vaccines, Inactivated
Viruses
Vitamin D
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Beschreibung
Zusammenfassung:Individuals with type 2 diabetes mellitus experience high rates of influenza virus infection and complications. We compared the magnitude and duration of serologic response to trivalent influenza vaccine in adults aged 50–80 with and without type 2 diabetes mellitus. Serologic response to influenza vaccination was similar in both groups: greater fold‐increases in antibody titer occurred among participants with lower pre‐vaccination antibody titers. Waning of antibody titers was not influenced by diabetes status.
ISSN:1750-2640
1750-2659
DOI:10.1111/irv.12933