Vaccination Against SARS-CoV-2 Is Associated With a Lower Viral Load and Likelihood of Systemic Symptoms

Abstract Background Data conflict on whether vaccination decreases severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load. The objective of this analysis was to compare baseline viral load and symptoms between vaccinated and unvaccinated adults enrolled in a randomized trial of outp...

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Veröffentlicht in:	Open Forum Infectious Diseases 2022-05, Vol.9 (5), p.ofac066
Hauptverfasser:	Bramante, Carolyn T, Proper, Jennifer L, Boulware, David R, Karger, Amy B, Murray, Thomas, Rao, Via, Hagen, Aubrey, Tignanelli, Christopher J, Puskarich, Michael, Cohen, Ken, Liebovitz, David M, Klatt, Nichole R, Broedlow, Courtney, Hartman, Katrina M, Nicklas, Jacinda, Ibrahim, Sherehan, Zaman, Adnin, Saveraid, Hanna, Belani, Hrishikesh, Ingraham, Nicholas, Christensen, Grace, Siegel, Lianne, Sherwood, Nancy E, Fricton, Regina, Lee, Sam, Odde, David J, Buse, John B, Huling, Jared D
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Body mass index Coronaviruses Courier services Diarrhea Editor's Choice Health aspects Major Ribonuclease Severe acute respiratory syndrome Vaccination
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Zusammenfassung:	Abstract Background Data conflict on whether vaccination decreases severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load. The objective of this analysis was to compare baseline viral load and symptoms between vaccinated and unvaccinated adults enrolled in a randomized trial of outpatient coronavirus disease 2019 (COVID-19) treatment. Methods Baseline data from the first 433 sequential participants enrolling into the COVID-OUT trial were analyzed. Adults aged 30–85 with a body mass index (BMI) ≥25 kg/m2 were eligible within 3 days of a positive SARS-CoV-2 test and
ISSN:	2328-8957 2328-8957
DOI:	10.1093/ofid/ofac066