Advances in understanding meso‐cortico‐limbic‐striatal systems mediating risky reward seeking

The risk of an aversive consequence occurring as the result of a reward‐seeking action can have a profound effect on subsequent behavior. Such aversive events can be described as punishers, as they decrease the probability that the same action will be produced again in the future and increase the exploration of less risky alternatives. Punishment can involve the omission of an expected rewarding event (“negative” punishment) or the addition of an unpleasant event (“positive” punishment). Although many individuals adaptively navigate situations associated with the risk of negative or positive punishment, those suffering from substance use disorders or behavioral addictions tend to be less able to curtail addictive behaviors despite the aversive consequences associated with them. Here, we discuss the psychological processes underpinning reward seeking despite the risk of negative and positive punishment and consider how behavioral assays in animals have been employed to provide insights into the neural mechanisms underlying addictive disorders. We then review the critical contributions of dopamine signaling to punishment learning and risky reward seeking, and address the roles of interconnected ventral striatal, cortical, and amygdala regions to these processes. We conclude by discussing the ample opportunities for future study to clarify critical gaps in the literature, particularly as related to delineating neural contributions to distinct phases of the risky decision‐making process. Reward seeking can be potently modulated by the risk of an aversive event occurring: threat of reward omission (negative punishment) or concomitant delivery of an unpleasant stimulus (positive punishment) both cause animals to alter their behavior. In this review, we provide an overview of negative and positive punishment‐based models of risky reward seeking, discussing the relevance of these approaches to understanding neuropsychiatric diseases such as substance use and alcohol use disorders. We then review literature establishing the necessity of nodes within a meso‐cortico‐limbic‐striatal network that regulate these two types of risky reward seeking.