Elucidating the role of transiently hypoxic tumour cells on radiation resistance

Elucidating the role of transiently hypoxic tumour cells on radiation resistance

The link between hypoxic conditions and radiation sensitivity is well-established, however the dynamic nature of hypoxia is often overlooked. The contribution of acute/transient hypoxia versus chronic conditions to radiosensitivity has been investigated by Wadsworth et al. using two hypoxia markers...

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Veröffentlicht in:British journal of cancer 2022-04, Vol.126 (7), p.971-972
Hauptverfasser: Higgins, Geoff S., Hammond, Ester M.
Format: Artikel
Sprache:eng
Schlagworte:
631/67/327
631/80/82/23
Biomedical and Life Sciences
Biomedicine
Blood flow
Cancer Research
Cell Count
Cell Hypoxia
Drug Resistance
Editorial
Epidemiology
Humans
Hypoxia
Molecular Medicine
Neoplasms - radiotherapy
Oncology
Radiation
Radiation Tolerance
Radiosensitivity
Tumors
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Beschreibung
Zusammenfassung:The link between hypoxic conditions and radiation sensitivity is well-established, however the dynamic nature of hypoxia is often overlooked. The contribution of acute/transient hypoxia versus chronic conditions to radiosensitivity has been investigated by Wadsworth et al. using two hypoxia markers and pentoxifylline to increase blood flow to regions of transient hypoxia.
ISSN:0007-0920
1532-1827
DOI:10.1038/s41416-022-01741-6