Nasopharyngeal Pneumococcal Colonization Density Is Associated With Severe Pneumonia in Young Children in the Lao People’s Democratic Republic

Abstract Background No studies have explored the association between pneumococcal nasopharyngeal density and severe pneumonia using the World Health Organization (WHO) 2013 definition. In Lao People’s Democratic Republic (Lao PDR), we determine the association between nasopharyngeal pneumococcal den...

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Veröffentlicht in:	The Journal of infectious diseases 2022-04, Vol.225 (7), p.1266-1273
Hauptverfasser:	Carr, Olivia J J, Vilivong, Keoudomphone, Bounvilay, Laddaphone, Dunne, Eileen M, Lai, Jana Y R, Chan, Jocelyn, Vongsakid, Malisa, Changthongthip, Anisone, Siladeth, C, Ortika, Belinda, Nguyen, Cattram, Mayxay, Mayfong, Newton, Paul N, Mulholland, Kim, Do, Lien A H, Dubot-Pérès, Audrey, Satzke, Catherine, Dance, David A B, Russell, Fiona M
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Carrier State - epidemiology Child Child, Preschool Children Cross-Sectional Studies Humans Infant Laos - epidemiology Major and Brief Reports Nasopharynx Pneumococcal Infections Pneumococcal Vaccines Pneumonia Pneumonia - epidemiology Polymerase chain reaction Respiratory syncytial virus Serogroup Streptococcus infections Vaccines
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Zusammenfassung:	Abstract Background No studies have explored the association between pneumococcal nasopharyngeal density and severe pneumonia using the World Health Organization (WHO) 2013 definition. In Lao People’s Democratic Republic (Lao PDR), we determine the association between nasopharyngeal pneumococcal density and severe pneumonia in children. Methods A prospective observational study was undertaken at Mahosot Hospital, Vientiane, from 2014 to mid-2018. Children
ISSN:	0022-1899 1537-6613
DOI:	10.1093/infdis/jiab239