Stratification of chemotherapy-treated stage III colorectal cancer patients using multiplexed imaging and single-cell analysis of T-cell populations

Colorectal cancer (CRC) has one of the highest cancer incidences and mortality rates. In stage III, postoperative chemotherapy benefits

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Bibliographische Detailangaben
Veröffentlicht in:	Modern pathology 2022-04, Vol.35 (4), p.564-576
Hauptverfasser:	Stachtea, Xanthi, Loughrey, Maurice B., Salvucci, Manuela, Lindner, Andreas U., Cho, Sanghee, McDonough, Elizabeth, Sood, Anup, Graf, John, Santamaria-Pang, Alberto, Corwin, Alex, Laurent-Puig, Pierre, Dasgupta, Sonali, Shia, Jinru, Owens, Jonathan R., Abate, Samantha, Van Schaeybroeck, Sandra, Lawler, Mark, Prehn, Jochen H. M., Ginty, Fiona, Longley, Daniel B.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/105 13/51 14/19 631/67/1504/1885/1393 631/67/327 82/1 Biomarkers, Tumor Cancer CD3 antigen CD4 antigen CD45 antigen CD8 antigen Cell culture Chemotherapy Chemotherapy, Adjuvant Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - pathology Cytokeratin Foxp3 protein Humans Immunofluorescence Immunoregulation Laboratory Medicine Lymphocytes T Mathematical models Medicine Medicine & Public Health Metastases Neoplasm Recurrence, Local - pathology Neoplasm Staging Oxaliplatin Pathology Patients PD-1 protein Prognosis Quantitation Risk assessment Segmentation Single-Cell Analysis Statistical analysis T-Lymphocyte Subsets - cytology Tumor Microenvironment Tumors
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Beschreibung
Zusammenfassung:	Colorectal cancer (CRC) has one of the highest cancer incidences and mortality rates. In stage III, postoperative chemotherapy benefits
ISSN:	0893-3952 1530-0285
DOI:	10.1038/s41379-021-00953-0