Treatment resistance in psychiatry: state of the art and new directions

Treatment resistance affects 20–60% of patients with psychiatric disorders; and is associated with increased healthcare burden and costs up to ten-fold higher relative to patients in general. Whilst there has been a recent increase in the proportion of psychiatric research focussing on treatment res...

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Veröffentlicht in:	Molecular psychiatry 2022-01, Vol.27 (1), p.58-72
Hauptverfasser:	Howes, Oliver D., Thase, Michael E., Pillinger, Toby
Format:	Artikel
Sprache:	eng
Schlagworte:	692/53/2421 692/699/476 Anxiety Behavioral Sciences Biological Psychology Bipolar disorder Bipolar Disorder - therapy Depressive Disorder, Major - therapy Drug addiction Drug resistance Epidemiology Humans Medicine Medicine & Public Health Mental disorders Nervous system Neurosciences Obsessive compulsive disorder Obsessive-Compulsive Disorder - psychology Obsessive-Compulsive Disorder - therapy Panic Disorder Patients Perspective Pharmacotherapy Post traumatic stress disorder Psychiatry Schizophrenia Treatment resistance
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Beschreibung
Zusammenfassung:	Treatment resistance affects 20–60% of patients with psychiatric disorders; and is associated with increased healthcare burden and costs up to ten-fold higher relative to patients in general. Whilst there has been a recent increase in the proportion of psychiatric research focussing on treatment resistance ( R 2 = 0.71, p
ISSN:	1359-4184 1476-5578
DOI:	10.1038/s41380-021-01200-3