Low Tissue Creatine: A Therapeutic Target in Clinical Nutrition
Low tissue creatine characterizes many conditions, including neurodegenerative, cardiopulmonary, and metabolic diseases, with a magnitude of creatine shortfall often corresponds well to a disorder's severity. A non-invasive monitoring of tissue metabolism with magnetic resonance spectroscopy (M...
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| Veröffentlicht in: | Nutrients 2022-03, Vol.14 (6), p.1230 |
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| creator | Ostojic, Sergej M |
| description | Low tissue creatine characterizes many conditions, including neurodegenerative, cardiopulmonary, and metabolic diseases, with a magnitude of creatine shortfall often corresponds well to a disorder's severity. A non-invasive monitoring of tissue metabolism with magnetic resonance spectroscopy (MRS) might be a feasible tool to evaluate suboptimal levels of creatine for both predictive, diagnostic, and therapeutic purposes. This mini review paper summarizes disorders with deficient creatine levels and provides arguments for assessing and employing tissue creatine as a relevant target in clinical nutrition. |
| doi_str_mv | 10.3390/nu14061230 |
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A non-invasive monitoring of tissue metabolism with magnetic resonance spectroscopy (MRS) might be a feasible tool to evaluate suboptimal levels of creatine for both predictive, diagnostic, and therapeutic purposes. This mini review paper summarizes disorders with deficient creatine levels and provides arguments for assessing and employing tissue creatine as a relevant target in clinical nutrition.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu14061230</identifier><identifier>PMID: 35334887</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adenosine triphosphate ; Autism ; Bioenergetics ; Biomarkers ; Biopsy ; Brain cancer ; Brain research ; Cardiomyopathy ; Clinical nutrition ; Creatine ; Creatine - metabolism ; Energy ; Hepatitis ; HIV ; Human immunodeficiency virus ; Lung cancer ; Magnetic Resonance Imaging - methods ; Magnetic resonance spectroscopy ; Magnetic Resonance Spectroscopy - methods ; Malnutrition ; Metabolic disorders ; Metabolism ; Metabolites ; Multiple sclerosis ; Muscular dystrophy ; Musculoskeletal system ; Neuromuscular diseases ; Nutrition ; Nutrition therapy ; Parkinson's disease ; Prostate ; Review ; Spectrum analysis ; Therapeutic applications ; Therapeutic targets ; Tissues ; Traumatic brain injury ; Tumors</subject><ispartof>Nutrients, 2022-03, Vol.14 (6), p.1230</ispartof><rights>2022 by the author. 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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access |
| subjects | Adenosine triphosphate Autism Bioenergetics Biomarkers Biopsy Brain cancer Brain research Cardiomyopathy Clinical nutrition Creatine Creatine - metabolism Energy Hepatitis HIV Human immunodeficiency virus Lung cancer Magnetic Resonance Imaging - methods Magnetic resonance spectroscopy Magnetic Resonance Spectroscopy - methods Malnutrition Metabolic disorders Metabolism Metabolites Multiple sclerosis Muscular dystrophy Musculoskeletal system Neuromuscular diseases Nutrition Nutrition therapy Parkinson's disease Prostate Review Spectrum analysis Therapeutic applications Therapeutic targets Tissues Traumatic brain injury Tumors |
| title | Low Tissue Creatine: A Therapeutic Target in Clinical Nutrition |
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