Low Tissue Creatine: A Therapeutic Target in Clinical Nutrition

Low Tissue Creatine: A Therapeutic Target in Clinical Nutrition

Low tissue creatine characterizes many conditions, including neurodegenerative, cardiopulmonary, and metabolic diseases, with a magnitude of creatine shortfall often corresponds well to a disorder's severity. A non-invasive monitoring of tissue metabolism with magnetic resonance spectroscopy (M...

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Veröffentlicht in:Nutrients 2022-03, Vol.14 (6), p.1230
1. Verfasser: Ostojic, Sergej M
Format: Artikel
Sprache:eng
Schlagworte:
Adenosine triphosphate
Autism
Bioenergetics
Biomarkers
Biopsy
Brain cancer
Brain research
Cardiomyopathy
Clinical nutrition
Creatine
Creatine - metabolism
Energy
Hepatitis
HIV
Human immunodeficiency virus
Lung cancer
Magnetic Resonance Imaging - methods
Magnetic resonance spectroscopy
Magnetic Resonance Spectroscopy - methods
Malnutrition
Metabolic disorders
Metabolism
Metabolites
Multiple sclerosis
Muscular dystrophy
Musculoskeletal system
Neuromuscular diseases
Nutrition
Nutrition therapy
Parkinson's disease
Prostate
Review
Spectrum analysis
Therapeutic applications
Therapeutic targets
Tissues
Traumatic brain injury
Tumors
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Zusammenfassung:Low tissue creatine characterizes many conditions, including neurodegenerative, cardiopulmonary, and metabolic diseases, with a magnitude of creatine shortfall often corresponds well to a disorder's severity. A non-invasive monitoring of tissue metabolism with magnetic resonance spectroscopy (MRS) might be a feasible tool to evaluate suboptimal levels of creatine for both predictive, diagnostic, and therapeutic purposes. This mini review paper summarizes disorders with deficient creatine levels and provides arguments for assessing and employing tissue creatine as a relevant target in clinical nutrition.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu14061230