Association of COVID-19 Vaccination in Pregnancy With Adverse Peripartum Outcomes

Association of COVID-19 Vaccination in Pregnancy With Adverse Peripartum Outcomes

IMPORTANCE: There is limited comparative epidemiological evidence on outcomes associated with COVID-19 vaccination during pregnancy; monitoring pregnancy outcomes in large populations is required. OBJECTIVE: To evaluate peripartum outcomes following COVID-19 vaccination during pregnancy. DESIGN, SET...

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Veröffentlicht in:JAMA : the journal of the American Medical Association 2022-04, Vol.327 (15), p.1478-1487
Hauptverfasser: Fell, Deshayne B, Dhinsa, Tavleen, Alton, Gillian D, Török, Eszter, Dimanlig-Cruz, Sheryll, Regan, Annette K, Sprague, Ann E, Buchan, Sarah A, Kwong, Jeffrey C, Wilson, Sarah E, Håberg, Siri E, Gravel, Christopher A, Wilson, Kumanan, El-Chaâr, Darine, Walker, Mark C, Barrett, Jon, MacDonald, Shannon E, Okun, Nannette, Shah, Prakesh S, Dougan, Shelley D, Dunn, Sandra, Bisnaire, Lise
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Apgar score
Cesarean section
Chorioamnionitis
Chorioamnionitis - epidemiology
Chorioamnionitis - etiology
Cohort Studies
Comments
Coronaviruses
COVID-19 - epidemiology
COVID-19 - prevention & control
COVID-19 vaccines
COVID-19 Vaccines - adverse effects
Epidemiology
Female
Hemorrhage
Humans
Immunization
Infant, Newborn
Infant, Newborn, Diseases - epidemiology
mRNA
mRNA Vaccines
Neonates
Online First
Ontario - epidemiology
Original Investigation
Peripartum Period
Population studies
Postpartum
Postpartum Hemorrhage - epidemiology
Postpartum Hemorrhage - etiology
Pregnancy
Pregnancy Outcome - epidemiology
Retrospective Studies
Risk
Robustness (mathematics)
Statistical analysis
Vaccination - adverse effects
Vaccines
Vaccines, Synthetic
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Zusammenfassung:IMPORTANCE: There is limited comparative epidemiological evidence on outcomes associated with COVID-19 vaccination during pregnancy; monitoring pregnancy outcomes in large populations is required. OBJECTIVE: To evaluate peripartum outcomes following COVID-19 vaccination during pregnancy. DESIGN, SETTING, AND PARTICIPANTS: Population-based retrospective cohort study in Ontario, Canada, using a birth registry linked with the provincial COVID-19 immunization database. All births between December 14, 2020, and September 30, 2021, were included. EXPOSURES: COVID-19 vaccination during pregnancy, COVID-19 vaccination after pregnancy, and no vaccination. MAIN OUTCOMES AND MEASURES: Postpartum hemorrhage, chorioamnionitis, cesarean delivery (overall and emergency cesarean delivery), admission to neonatal intensive care unit (NICU), and low newborn 5-minute Apgar score (
ISSN:0098-7484
1538-3598
DOI:10.1001/jama.2022.4255