Colorectal Cancer‐Derived Small Extracellular Vesicles Promote Tumor Immune Evasion by Upregulating PD‐L1 Expression in Tumor‐Associated Macrophages (Adv. Sci. 9/2022)

Colorectal Cancer‐Derived Small Extracellular Vesicles Promote Tumor Immune Evasion by Upregulating PD‐L1 Expression in Tumor‐Associated Macrophages (Adv. Sci. 9/2022)

Small Extracellular Vesicles In colorectal cancer (CRC) tissues, tumor cell‐derived small extracellular vesicles (sEVs) miR‐21‐5p and miR‐200a synergistically induce macrophage M2 like polarization and PD‐L1 expression by regulating the PTEN/AKT and SCOS1/STAT1 pathways, resulting in decreased CD8+...

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Veröffentlicht in:Advanced science 2022-03, Vol.9 (9), p.n/a
Hauptverfasser: Yin, Yuan, Liu, Bingxin, Cao, Yulin, Yao, Surui, Liu, Yuhang, Jin, Guoying, Qin, Yan, Chen, Ying, Cui, Kaisa, Zhou, Leyuan, Bian, Zehua, Fei, Bojian, Huang, Shenglin, Huang, Zhaohui
Format: Artikel
Sprache:eng
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Extracellular vesicles
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Zusammenfassung:Small Extracellular Vesicles In colorectal cancer (CRC) tissues, tumor cell‐derived small extracellular vesicles (sEVs) miR‐21‐5p and miR‐200a synergistically induce macrophage M2 like polarization and PD‐L1 expression by regulating the PTEN/AKT and SCOS1/STAT1 pathways, resulting in decreased CD8+ T cell activity and increased tumor growth. More details can be found in article number 202102620 by Shenglin Huang, Zhaohui Huang, and co‐workers.
ISSN:2198-3844
2198-3844
DOI:10.1002/advs.202270057