Design, synthesis and anti-mycobacterial evaluation of imidazo[1,2- a ]pyridine analogues

Based on the molecular hybridization strategy, thirty-four imidazo[1,2- ]pyridine amides (IPAs) and imidazo[1,2- ]pyridine sulfonamides (IPSs) were designed and synthesized. The structures of the target compounds were characterized using H NMR, C NMR, LCMS, and elemental analyses. The synthesized compounds were evaluated for anti-tubercular activity using the microplate Alamar Blue assay against H37Rv strain and the MIC was determined. The evaluated compounds exhibited MIC in the range 0.05-≤100 μg mL . Among these derivatives, 6 (MIC 0.05 μg mL ), 9 (MIC 0.4 μg mL ), and 1 (MIC 0.4 μg mL ) displayed excellent anti-TB activity, whereas compounds 5, 7 and 16 showed good anti-TB activity (MIC 0.8-3.12 μg mL ). The most active compounds with MIC of