Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins

The in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin were tested against 72 ciprofloxacin-resistant and 28 ciprofloxacin-susceptible isolates of Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 1999-08, Vol.43 (8), p.2051-2055
Hauptverfasser:	BRISSE, S, MILATOVIC, D, FLUIT, A. C, VERHOEF, J, MARTIN, N, SCHEURING, S, KÖHRER, K, SCHMITZ, F.-J
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Infective Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Aza Compounds Biological and medical sciences Ciprofloxacin - pharmacology DNA Gyrase DNA Topoisomerase IV DNA Topoisomerases, Type II - genetics DNA Topoisomerases, Type II - physiology Enterobacter aerogenes Enterobacter cloacae Enterobacter cloacae - drug effects Enterobacter cloacae - genetics Enterobacter cloacae - isolation & purification Fluoroquinolones Humans Klebsiella oxytoca Klebsiella pneumoniae Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - genetics Klebsiella pneumoniae - isolation & purification Levofloxacin Medical sciences Microbial Sensitivity Tests Molecular Sequence Data Naphthyridines - pharmacology Ofloxacin - pharmacology Pharmacology. Drug treatments Quinolines Susceptibility
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Zusammenfassung:	The in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin were tested against 72 ciprofloxacin-resistant and 28 ciprofloxacin-susceptible isolates of Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes. Irrespective of the alterations in GyrA and ParC proteins, clinafloxacin exhibited greater activity than all other fluoroquinolones tested against K. pneumoniae and E. aerogenes.
ISSN:	0066-4804 1098-6596
DOI:	10.1128/AAC.43.8.2051