C–H Amination via Electrophotocatalytic Ritter-type Reaction

C–H Amination via Electrophotocatalytic Ritter-type Reaction

A method for C–H bond amination via an electrophotocatalytic Ritter-type reaction is described. The reaction is catalyzed by a trisaminocyclopropenium (TAC) ion in an electrochemical cell under irradiation. These conditions convert benzylic C–H bonds to acetamides without the use of a stoichiometric...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of the American Chemical Society 2021-06, Vol.143 (23), p.8597-8602
Hauptverfasser: Shen, Tao, Lambert, Tristan H
Format: Artikel
Sprache:eng
Schlagworte:
Acetamides - chemical synthesis
Acetamides - chemistry
Amination
Catalysis
Cyclopropanes - chemistry
Molecular Structure
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A method for C–H bond amination via an electrophotocatalytic Ritter-type reaction is described. The reaction is catalyzed by a trisaminocyclopropenium (TAC) ion in an electrochemical cell under irradiation. These conditions convert benzylic C–H bonds to acetamides without the use of a stoichiometric chemical oxidant. A range of functionality is shown to be compatible with this transformation, and several complex substrates are demonstrated.
ISSN:0002-7863
1520-5126
DOI:10.1021/jacs.1c03718