Closing the gap: Tricellulin/α-catenin interaction maintains epithelial integrity at vertices

Closing the gap: Tricellulin/α-catenin interaction maintains epithelial integrity at vertices

Tricellular junctions play a critical role in regulating epithelial barrier function. In this issue, Cho et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202009037) demonstrate a novel interaction between tricellulin and α-catenin, which connects tricellular junctions to the actomyosin cytoske...

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Veröffentlicht in:The Journal of cell biology 2022-04, Vol.221 (4), p.1
Hauptverfasser: van den Goor, Lotte, Miller, Ann L
Format: Artikel
Sprache:eng
Schlagworte:
Actin Cytoskeleton
Actomyosin
alpha Catenin - genetics
Apexes
MARVEL Domain Containing 2 Protein
Spotlight
Tight Junctions
α-Catenin
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Zusammenfassung:Tricellular junctions play a critical role in regulating epithelial barrier function. In this issue, Cho et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202009037) demonstrate a novel interaction between tricellulin and α-catenin, which connects tricellular junctions to the actomyosin cytoskeleton, thus supporting the epithelial barrier at cell vertices.
ISSN:0021-9525
1540-8140
DOI:10.1083/jcb.202202009